1383549-86-7

Basic information

• Product Name: 3-(4-fluorophenyl)isoquinoline
• Synonyms: 3-(4-fluorophenyl)isoquinoline
• CAS NO: 1383549-86-7
• Molecular Weight: 223.25
• Mol File: 1383549-86-7.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)isoquinoline(1383549-86-7)
• EPA Substance Registry System: 3-(4-fluorophenyl)isoquinoline(1383549-86-7)

Safety Data

• Hazardous Substances Data: 1383549-86-7(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1042369-43-6 2-[2-(4-fluorophenyl)ethynyl]benzaldehyde 
• 1426258-77-6 3-(4-fluorophenyl)isoquinoline N-oxide 
• 1401453-22-2 2-(2-(4-fluorophenyl)ethynyl)benzaldehyde oxime 
• 1765-93-1 4-fluoroboronic acid 
• 135737-14-3 2-(2-formylphenyl)acetonitrile 
• 212505-57-2 N-(2-iodobenzylidene)-2-methylpropan-2-amine 
• 26260-02-6 2-iodobenzaldehyde 
• 50624-28-7 1-(isoquinolin-2(1H)-yl)ethan-1-one 
• 119-65-3 isoquinoline 
• 100-46-9 benzylamine 
• 18904-38-6 N-benzyl-2-pyridinecarboxamide 
• 193675-43-3 N-(4-fluorobenzylidene)-4-methylbenzenesulfonamide 

Relevant articles and documents

Silver/Rhodium Relay Catalysis Enables C?H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds

Employing silver/rhodium relay catalysis strategy, an intramolecular electrophilic cyclization and C?H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23–88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments. (Figure presented.).

Catalyst and additive free 6-endo-dig cyclization of ortho-alkynylarylaldimines in water: An environmentally friendly access to isoquinolines

A novel and sustainable route for the synthesis of isoquinoline was developed by reacting 2-ethynylbenzaldehyde with ammonium hydroxide in water. This method provides a convenient, atom-economical, and catalyst-free access to diversely substituted isoquinolines with moderate to good yields.

An efficient approach to isoquinoline via AgNO3-promoted 6-endo-dig cyclization followed by oxidative elimination of o-alkynylarylaldimines and its application in fluoride recognition

A novel 6-endo-dig cyclization followed by oxidation/elimination of o-alkynylarylaldimines with 4-hydroxybenzylamine was developed for preparation of isoquinolines. The intermediates of this tandem reaction were monitored by mass spectroscopy (MS) to confirm the reaction pathway. This methodology was further applied to the design and synthesis of a novel ratiometric chemosensor for determination of fluoride.