1383550-72-8Relevant academic research and scientific papers
Electrochemically initiated tandem and sequential conjugate addition processes: One-pot synthesis of diverse functionalized isoindolinones
Antico, Pasqualmorica,Capaccio, Vito,Di Mola, Antonia,Massa, Antonio,Palombi, Laura
, p. 1717 - 1724 (2012)
A tandem aldol-heterocyclization-rearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors. Copyright
