1383604-53-2Relevant academic research and scientific papers
Design and synthesis of a novel class of CK2 inhibitors: Application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles
Suzuki, Yamato,Oishi, Shinya,Takei, Yoshinori,Yasue, Misato,Misu, Ryosuke,Naoe, Saori,Hou, Zengye,Kure, Tatsuhide,Nakanishi, Isao,Ohno, Hiroaki,Hirasawa, Akira,Tsujimoto, Gozoh,Fujii, Nobutaka
, p. 4907 - 4915 (2012/08/08)
Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure-activity relationship (SAR) studies. Various dipyrrolo[3,2-b:2′,3′-e]pyridine and benzo[g]indazole derivatives were prepared using transition-metal-catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo[g]indazole is a promising scaffold for potent CK2 inhibitors. The inhibitory activities on cell proliferation of these potent CK2 inhibitors are also presented.
