356101-62-7

Upstream product

• 1383604-52-1 methyl 2-(4-methoxybenzyl)hydrazinecarboxylate 
• 6294-89-9 hydrazinecarboxylic acid methyl ester 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1383604-52-1 methyl 2-(4-methoxybenzyl)hydrazinecarboxylate 
• 1383604-54-3 dimethyl 2-(4-methoxybenzyl)-4-(4-methoxyphenyl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 
• 1383604-53-2 dimethyl 2-(4-methoxybenzyl)-4-phenyl-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 
• 1383604-55-4 dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(4-methoxyphenyl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 
• 1383604-56-5 dimethyl 2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 
• 1383604-57-6 dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 
• 1383604-58-7 dimethyl 2-(4-methoxybenzyl)-4-propyl-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate 

Relevant academic research and scientific papers

Au(I) Catalyzed Synthesis of Densely Substituted Pyrazolines and Dihydropyridines via Sequential Aza-Enyne Metathesis/6π-Electrocyclization

A gold(I) autotandem catalysis protocol is reported for the de novo synthesis of densely substituted pyrazolines and dihydropyridines from the corresponding imine derivatives in a highly regioselective fashion via a one-pot aza-enyne metathesis/6π-electrocyclization sequence. The substituents on the nitrogen atom of the imine perfectly control the reaction pathways from the pivotal 1-azabutadiene intermediate; thus, carbazates were converted into pyrazolines via 6π-electrocyclization of α,β-unsaturated hydrazones, while aryl imines provided dihydropyridines via 6π-electrocyclization of 3-azahexatrienes.

Phenylhydrazone fluorescent probe, preparation and applications thereof

The invention discloses a phenylhydrazone fluorescent probe, a preparation and applications thereof. According to the present invention, the fluorescence of the phenylhydrazone fluorescent probe can be enhanced in Al, Ba, Cu, Hg, Mg, Ag, Ni and Zn, can be even enhanced by more than 20 times in Mg and Ni, and is almost completely quenched in Fe, such thatthe results show that the complexed phenylhydrazone has good selectivity on iron metal ions, and can be used for the naked eye qualitative identification of iron ions.

I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement

A simple and efficient iodine-assisted protocol for the synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones has been developed. The reaction involves a sequential condensation followed by tandem oxidative cyclization and rearrangement of

Metal-Free Synthesis of 1,3,4-Oxadiazoles from N′-(Arylmethyl)hydrazides or 1-(Arylmethyl)-2-(arylmethylene)hydrazines

An efficient and versatile metal-free synthesis of 1,3,4-oxadiazoles from N′-(arylmethyl)hydrazides or 1-(arylmethyl)-2-(arylmethylene)hydrazines through oxidative dehydrogenation is reported. A range of 2,5-disubstituted 1,3,4-oxadiazoles were prepared by treating N′-(arylmethyl)hydrazides with (diacetoxyiodo)benzene in acetonitrile or by treating 1-(arylmethyl)-2-(arylmethylene)hydrazines with [bis(trifluoroacetoxy)iodo]benzene in methyl tert-butyl ether. Aldehyde N-acylhydrazones and aldazines were initially generated in situ as intermediates.

Design and synthesis of a novel class of CK2 inhibitors: Application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles

Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure-activity relationship (SAR) studies. Various dipyrrolo[3,2-b:2′,3′-e]pyridine and benzo[g]indazole derivatives were prepared using transition-metal-catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo[g]indazole is a promising scaffold for potent CK2 inhibitors. The inhibitory activities on cell proliferation of these potent CK2 inhibitors are also presented.

An efficient solid-phase synthesis of 3-substituted and 3,3-disubstituted 1,2-dialkylpyrazolidine-3,5-diones

An efficient and regioselective procedure for the synthesis of di-, tri- and fully-substituted pyrazolidine-3,5-diones on a solid-phase format is described. Microwave irradiation provided significant rate enhancement in this protocol. To demonstrate the v