1383708-72-2

Upstream product

• 1383709-54-3 4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine 
• 124-63-0 methanesulfonyl chloride 
• 116632-24-7 2-amino-4,6-dichloropyridine 
• 1355052-34-4 2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1383709-55-4 N-allyl-N-(4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)methanesulfonamide 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINES AS SODIUM CHANNEL BLOCKERS

The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.