1383714-46-2

Upstream product

• 864076-04-0 methyl 4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 349536-24-9 4-[(3'-methoxycarbonylpropyl)oxy]-3-methoxy-2-nitrobenzoic acid 
• 176375-42-1 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester 
• 121-33-5 vanillin 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 
• 1314533-98-6 4-(((11aS)-10-((allyloxy)carbonyl)-7-methoxy-5-oxo-11-((tetrahydro-2H- pyran-2-yl)oxy)-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4] diazepin-8-yl)oxy)butanoic acid 
• 864076-02-8 methyl 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 1196-90-3 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 96-54-8 N-Methylpyrrole 
• 184643-69-4 1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 864672-97-9 (11S,11aS)-11-hydroxy-7-methoxy-8-(3-methoxycarbonylpropoxy)-5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzodiazepine-10-carboxylic acid allyl ester 
• 909415-16-3 4-[5-allyloxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]butanoic acid methyl ester 
• 909415-15-2 4-[5-amino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]butanoic acid methyl ester 

Relevant academic research and scientific papers

POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are useful as medicaments, in particular for use as a drug in an antibody-drug conjugate and in the treatment of a proliferative disease, a bacterial infection, a malarial infection and inflammation.

PYRROLOBENZODIAZEPINES

Pyrrolobenzodiazepine (PBDs) having a (1-methyl-1H-pyrrol-3- yl)phenyl based amino residue were found to be highly effective compounds having improved cytotoxicity ad DNA binding properties.

GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models

DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce