138381-24-5

Upstream product

• 13122-67-3 6-phenyl-4-oxohexanoic acid 
• 112607-22-4 (+)-(R)-5-(2-phenylethyl)dihydrofuran-2(3H)-one 
• 75989-44-5 (S)-5-(1'-oxo-2'-phenylethyl)dihydrofuran-2(3H)-one 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 54848-33-8 (S)-tetrahydro-5-oxo-2-furancarbonyl chloride 
• 145761-24-6 (5S,1'S)-5-(1'-methanesulfonyloxy-2'-phenylethyl)dihydrofuran-2(3H)-one 
• 125225-52-7 (5S,1'S)-5-(1'-hydroxy-2'-phenylethyl)dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster

Baker's yeast reduction of arylalkyl and arylalkenil γ- and δ-keto acids

γ- and δ-Lactones 5, 6, 13, 14, 15 and 16 were synthesized via baker's yeast reduction of the corresponding keto acids 3, 4 and 9-12. The enantioselectivity of the reduction is strongly dependent on the nature of the keto acid; the δ-lactones ware always obtained in an ee% higher than the γ-lactones and ranging from 70% to 100%.