125225-52-7Relevant academic research and scientific papers
LATERAL ROOT INDUCING COMPOUNDS FROM THE BACTERIUM ERWINIA QUERCINA: ISOLATION, STRUCTURE AND SYNTHESIS
Wright, Amy E.,Schaefer, Matthias,Midland, Sharon,Munnecke, Donald E.,Sims, James J.
, p. 5699 - 5702 (1989)
The structures lateral root inducing compounds produced in culture by the bacterium Erwinia quercina were shown to be two diastereomers of 4,5-dihydroxy-6-phenylhexanoic acid.All four chiral isomers of the active structure were synthesized.
A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (-)- and (+)-muricatacin
Wang,Zhang,Sharpless,Sinha,Sinha Bagchi,Keinan
, p. 6407 - 6410 (1992)
Both enantiomers of hydroxy γ-lactones have been prepared highly enantioselectively (92-99% ee) using either AD-mix-β or AD-mix-α with both β,γ- and γ,δ-unsaturated esters. The method is exemplified by the three-step synthesis of (-) and (+)-muricatacin i
Selective addition of Grignard reagents to 2,3-O-isopropylidene bis-Weinreb tartaric acid amide
McNulty, James,Grunner, Veronika,Mao, Justin
, p. 5609 - 5612 (2007/10/03)
Controlled addition of Grignard reagents to tartaric acid derived bis-Weinreb amide 3 provides a facile, direct entry to desymmetrized 1,4-functionalized-syn-2,3-diol intermediates 4 and to C2-symmetrical 1,4-diketones 5. The synthetic versatil
Novel small renin inhibitors containing 4,5- or 3,5-Dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites
Jung, Grace L.,Anderson, Paul C.,Bailey, Murray,Baillet, Monique,Bantle, Gary W.,Berthiaume, Sylvie,Lavallee, Pierre,Llinas-Brunet, Montse,Thavonekham, Bounkham,Thibeault, Diane,Simoneau, Bruno
, p. 2317 - 2336 (2007/10/03)
Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P2-P3 sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesi
Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences
Sakurai,Higashida,Sugano,Nishi,Saito,Ohata,Handa,Komai,Yagi,Nishigaki,Yabe
, p. 1378 - 1386 (2007/10/02)
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster
Synthesis of Lateral Root-Inducing Compounds Using an Efficient Coupling Reaction of Chiral Triflates
Kotsuki, Hiyoshizo,Miyazaki, Aya,Ochi, Masamitsu,Sims, James J.
, p. 721 - 723 (2007/10/02)
Lateral root-inducing compounds, isolated from the bacterium Erwinia quercina, have been synthesized by using a coupling reaction of chiral triflates derived from L- or D-tartrates and their biological activities examined.
DIASTEREOSELECTIVITY IN THE DIRECTED ALDOL CONDENSATION OF 2-TRIMETHYLSILOXYFURAN WITH ALDEHYDES. A STEREODIVERGENT ROUTE TO THREO AND ERYTHRO δ-HYDROXY-γ-LACTONES
Jefford, Charles W.,Jaggi, Danielle,Boukouvalas, John
, p. 4037 - 4040 (2007/10/02)
Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).
