1383813-06-6

Basic information

• Product Name: 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea
• CAS NO: 1383813-06-6
• Molecular Weight: 352.177
• Mol File: 1383813-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea(1383813-06-6)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea(1383813-06-6)

Safety Data

• Hazardous Substances Data: 1383813-06-6(Hazardous Substances Data)

Upstream product

• 95-25-0 5-chloro-2-benzoxazolinone 
• 5790-90-9 5-chloro-3-methyl-1,3-benzoxazol-2(3H)-one 
• 81117-78-4 6-amino-5-chloro-3-methylbenzo[d]oxazol-2(3H)-one 
• 104-12-1 p-chlorphenylisocyanate 
• 81117-74-0 5-chloro-3-methyl-6-nitrobenzo[d]oxazol-2(3H)-one 

Relevant articles and documents

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/ chloro-3-methyl-2(3H) -benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by 1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 ig/mL when compared with the other target compounds.