81117-74-0

Upstream product

• 95-25-0 5-chloro-2-benzoxazolinone 
• 5790-90-9 5-chloro-3-methyl-1,3-benzoxazol-2(3H)-one 

Downstream Products

• 1383813-05-5 1-phenyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-06-6 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-07-7 1-(4-methoxyphenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-08-8 1-benzyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 81117-78-4 6-amino-5-chloro-3-methylbenzo[d]oxazol-2(3H)-one 

Relevant academic research and scientific papers

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for t

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/ chloro-3-methyl-2(3H) -benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by 1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 ig/mL when compared with the other target compounds.