5790-90-9

Basic information

• Product Name: 5-Chloro-3-methylbenzoxazol-2(3H)-one
• Synonyms: 5-Chloro-3-methylbenzoxazol-2(3H)-one
• CAS NO: 5790-90-9
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.5917
• Mol File: 5790-90-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 294°Cat760mmHg
• Flash Point: 131.6°C
• Appearance: /
• Density: 1.422g/cm³
• Vapor Pressure: 0.00167mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 5-Chloro-3-methylbenzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-methylbenzoxazol-2(3H)-one(5790-90-9)
• EPA Substance Registry System: 5-Chloro-3-methylbenzoxazol-2(3H)-one(5790-90-9)

Safety Data

• Statements: 20/21/22-33-36/38
• Safety Statements: 26-28-36/37
• TSCA: No
• Hazardous Substances Data: 5790-90-9(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-methylbenzoxazol-2(3H)-one is a chemical compound with the molecular formula C8H6ClNO2. It is a benzoxazolone derivative that is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It exhibits antifungal and antibacterial properties, making it a valuable ingredient in the development of new drugs and agrochemical products. Additionally, it has been studied for its potential use in the treatment of neurological disorders, inflammatory conditions, and cancer. 5-Chloro-3-methylbenzoxazol-2(3H)-one is a versatile and important chemical in the field of medicinal and agrochemical research due to its diverse range of potential applications.

InChI:InChI=1/C8H6ClNO2/c1-10-6-4-5(9)2-3-7(6)12-8(10)11/h2-4H,1H3

Upstream product

• 95-85-2 2-hydroxy-5-chloro-aniline 
• 95-25-0 5-chloro-2-benzoxazolinone 
• 74-88-4 methyl iodide 
• 61-80-3 zoxazolamine 
• 77-78-1 dimethyl sulfate 
• 64037-23-6 5-chloro-3-methyl-3H-benzoxazol-2-one-imine 
• 67-56-1 methanol 
• 117124-13-7 5-chloro-2-dimethylamino-3-methyl-benzoxazolium; iodide 

Downstream Products

• 81117-78-4 6-amino-5-chloro-3-methylbenzo[d]oxazol-2(3H)-one 
• 81117-74-0 5-chloro-3-methyl-6-nitrobenzo[d]oxazol-2(3H)-one 
• 1383813-17-9 1-benzyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-16-8 1-(4-methoxyphenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-15-7 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-14-6 1-phenyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-08-8 1-benzyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-07-7 1-(4-methoxyphenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-06-6 1-(4-chlorophenyl)-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-05-5 1-phenyl-3-(5-chloro-3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1153740-75-0 C₁₅H₉Cl₂NO₃ 
• 1153740-76-1 C₁₅H₉Cl₂NO₃ 
• 1153740-77-2 C₁₅H₉Cl₂NO₃ 
• 97693-73-7 C₁₅H₁₀ClNO₃ 

Relevant articles and documents

Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors

The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/ chloro-3-methyl-2(3H) -benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by 1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 ig/mL when compared with the other target compounds.

Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties

In this study, eight new 1-(2-benzoxazolinone-6-yl)-2-(4-arylpiperazine-1-yl)ethanol and -propanol derivatives have been prepared. Their structures have been elucidated by IR- and 1H-NMR-spectra and by elementary analysis. The analgesic activit