5790-90-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-3-methylbenzoxazol-2(3H)-one is used as a building block for the synthesis of various pharmaceuticals for its antifungal and antibacterial properties. It aids in the development of new drugs to combat infections and diseases.
Used in Agrochemical Industry:
5-Chloro-3-methylbenzoxazol-2(3H)-one is used as a building block for the synthesis of various agrochemicals for its antifungal and antibacterial properties. It contributes to the development of new products to protect crops and enhance agricultural productivity.
Used in Neurological Disorder Treatment:
5-Chloro-3-methylbenzoxazol-2(3H)-one is studied for its potential use in the treatment of neurological disorders. Its properties are being investigated for their possible therapeutic effects on conditions affecting the nervous system.
Used in Inflammatory Condition Treatment:
5-Chloro-3-methylbenzoxazol-2(3H)-one is studied for its potential use in the treatment of inflammatory conditions. Its properties are being explored for their possible benefits in reducing inflammation and managing related symptoms.
Used in Cancer Treatment:
5-Chloro-3-methylbenzoxazol-2(3H)-one is studied for its potential use in the treatment of cancer. Its properties are being researched for their possible anticancer effects and contribution to the development of novel therapeutic agents.

InChI:InChI=1/C8H6ClNO2/c1-10-6-4-5(9)2-3-7(6)12-8(10)11/h2-4H,1H3

Upstream product

• 64037-23-6 5-chloro-3-methyl-3H-benzoxazol-2-one-imine 
• 95-25-0 5-chloro-2-benzoxazolinone 
• 77-78-1 dimethyl sulfate 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 74-88-4 methyl iodide 
• 61-80-3 zoxazolamine 
• 67-56-1 methanol 
• 117124-13-7 5-chloro-2-dimethylamino-3-methyl-benzoxazolium; iodide 

Downstream Products

• 132634-41-4 1-(5-chloro-3-methyl-2-benzoxazolone-6-yl)-2-<4-(2-methoxyphenyl)piperazine-1-yl>ethanol 
• 132634-42-5 5-Chloro-6-{1-hydroxy-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-47-0 5-Chloro-6-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-1-hydroxy-propyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-47-0 5-Chloro-6-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-1-hydroxy-propyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-45-8 5-Chloro-6-{1-hydroxy-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-45-8 5-Chloro-6-{1-hydroxy-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-43-6 5-Chloro-6-{1-hydroxy-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-propyl}-3-methyl-3H-benzooxazol-2-one 
• 132634-43-6 5-Chloro-6-{1-hydroxy-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-propyl}-3-methyl-3H-benzooxazol-2-one 
• 1153740-78-3 C₁₅H₈Cl₃NO₃ 
• 97693-73-7 C₁₅H₁₀ClNO₃ 
• 1153740-77-2 C₁₅H₉Cl₂NO₃ 
• 1153740-76-1 C₁₅H₉Cl₂NO₃ 
• 1153740-75-0 C₁₅H₉Cl₂NO₃ 

Relevant academic research and scientific papers

Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors

The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/ chloro-3-methyl-2(3H) -benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by 1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 ig/mL when compared with the other target compounds.

New imidazole derivatives of 2(3H)-benzazolones as potential antifungal agents

A series of new imidazole derivatives containing 2(3H)-benzoxazolone or 2(3H)-benzothiazolone ring were synthesized as analogues of the antifungal drug bifonazole. All compounds were tested in vitro against Candida albicans, Candida parapsilosis, and Cand

Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties

In this study, eight new 1-(2-benzoxazolinone-6-yl)-2-(4-arylpiperazine-1-yl)ethanol and -propanol derivatives have been prepared. Their structures have been elucidated by IR- and 1H-NMR-spectra and by elementary analysis. The analgesic activit