138399-44-7Relevant academic research and scientific papers
Cs2CO3-promoted defluorination and functionalization of α-CF3 carbonyl compounds in the presence of: N -, O -, and/or S -nucleophiles
Wu, Yue,Zhang, Bingbing,Zheng, Yinying,Wang, Yuheng,Lei, Xinsheng
, p. 16019 - 16023 (2018)
A simple, efficient, and mild method for defluorination and functionalization of 3,3,3-trifluoro carbonyl compounds has been developed. In the present method, Cs2CO3 can easily convert α-trifluoromethyl esters, amides, and ketones in
A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines
Ginzinger, Werner,Mühlgassner, Gerhard,Arion, Vladimir B.,Jakupec, Michael A.,Roller, Alexander,Galanski, Markus,Reithofer, Michael,Berger, Walter,Keppler, Bernhard K.
, p. 3398 - 3413 (2012/06/04)
A series of ruthenium(II) arene complexes with 3-(1H-benzimidazol-2-yl)-1H- quinoxalin-2-one, bearing pharmacophoric groups of known protein kinase inhibitors, and related benzoxazole and benzothiazole derivatives have been synthesized. In addition, the corresponding osmium complexes of the unsubstituted ligands have also been prepared. The compounds have been characterized by NMR, UV-vis, and IR spectroscopy, ESI mass spectrometry, elemental analysis, and by X-ray crystallography. Antiproliferative activity in three human cancer cell lines (A549, CH1, SW480) was determined by MTT assays, yielding IC50 values of 6-60 μM for three unsubstituted metal-free ligands, whereas values for the metal complexes vary in a broad range from 0.3 to 140 μM. Complexation with osmium of quinoxalinone derivatives with benzimidazole or benzothiazole results in a more consistent increase in cytotoxicity than complexation with ruthenium. For selected compounds, the capacity to induce apoptosis was confirmed by fluorescence microscopy and flow-cytometric analysis, whereas cell cycle effects are only moderate.
Monoazo or disazo pigments based on (benoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides
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, (2008/06/13)
Water-insoluble azo colorants, their preparation and use The invention relates to monoazo and disazo compounds of the formula (I) STR1 in which D is the radical of a carbocyclic or heterocyclic diazo or bisdiazo component, R1 and R2, independently of one another, are each a substituted or unsubstituted aryl or heteroaryl radical, X1 and X2, independently of one another, are each ring-forming ether oxygen or a substituted or unsubstituted imide grouping and n has the value 0 or 1, in which rings A and B, independently of one another, can each be additionally substituted and/or carry substituted or unsubstituted fused rings. These new compounds of the formula (I) are obtained by coupling diazotized amines or diamines of the type D--NH2 or H2 N--D--NH2 with (benzoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides. Depending on the presence and length of alkyl chains, the compounds of the formula (I) are suitable for use as pigments, disperse dyes or oil-soluble dyes.
