2318-25-4Relevant articles and documents
Synthesis of α-substituted 2-(1H-1,2,4-triazol-3-yl)acetates and 5-amino-2,4-dihydro-3H-pyrazol-3-ones via the Pinner strategy
Khomenko, Dmytro M.,Doroshchuk, Roman O.,Ivanova, Hanna V.,Zakharchenko, Borys V.,Raspertova, Ilona V.,Vaschenko, Oleksandr V.,Shova, Sergiu,Dobrydnev, Alexey V.,Moroz, Yurii S.,Grygorenko, Oleksandr O.,Lampeka, Rostyslav D.
supporting information, (2021/03/17)
A series of 2-(1H-1,2,4-triazol-3-yl)acetates, as well as 4-mono- and 4,4-disubstituted 5-amino-2,4-dihydro-3H-pyrazol-3-ones (including spirocyclic derivatives) have been synthesized using the Pinner reaction strategy. α-Mono- and α,α-disubstituted ethyl cyanoacetates were converted into the corresponding carboxyimidate salts that served as the key intermediates. Their further reaction with formylhydrazide or hydrazine hydrate provided triazolylacetates or aminopyrazolones (including spirocyclic derivatives), depending on the structure of the starting Pinner salt and the nature of the nucleophile. The scope and limitations of the developed synthetic method have been established.
1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES
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Paragraph 0150; 0428-0429, (2020/08/30)
The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.
Energetic compounds featuring bi(1,3,4-oxadiazole): a new family of insensitive energetic materials
Tian, Jiawei,Xiong, Hualin,Lin, Qiuhan,Cheng, Guangbin,Yang, Hongwei
, p. 1918 - 1924 (2017/03/09)
In this contribution, 5,5′-bis(trinitromethyl)-2,2′-bi(1,3,4-oxadiazole) (4) and 11 nitrogen-rich salts featuring bi(1,3,4-oxadiazole) were synthesised. Compound 4 was obtained by nitration of 2,2′-bi(1,3,4-oxadiazolyl)-5,5′-diacetic acid and the salts (6, 8-17) were prepared by facile deprotonation and metathesis reactions. All compounds were characterized by IR, multinuclear NMR spectroscopy and elemental analysis. The structures of 6, 9 and 15 were further confirmed by single crystal X-ray diffraction. The physicochemical as well as energetic properties of these compounds including density, thermal stability and sensitivity were investigated. Except for 12 and 15, most of the salts decompose at temperatures over 180 °C. The performance data from the calculated heats of formation and experimental densities indicate that many of the salts have potential applications as energetic materials. The tested sensitivities of these compounds illustrate that they are less sensitive than RDX towards impact, friction and electrostatic discharge.
