1384100-93-9Relevant academic research and scientific papers
Molecular symmetry and biological activities of new symmetrical tris(2-aminoethyl)amine derivatives
Mibu, Nobuko,Yokomizo, Kazumi,Uchida, Wataru,Takemura, Satoshi,Zhou, Jianrong,Aki, Hatsumi,Miyata, Takeshi,Sumoto, Kunihiro
, p. 408 - 414 (2012)
In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.
