Molecular symmetry and biological activities of new symmetrical tris(2-aminoethyl)amine derivatives

Article abstract of DOI:10.1248/cpb.60.408

In terms of molecular symmetry and bioactivity, new C₃- and C_S-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.