138420-09-4

Basic information

• Product Name: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE
• Synonyms: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE;Ethyl 2-(5-chloro-1,3-benzoxazol-2-yl)acetate;(5-Chloro-1,3-benzoxazol-2-yl)acetic acid ethyl ester, 5-Chloro-2-(2-ethoxy-2-oxoethyl)-1,3-benzoxazole;Ethyl (5-chloro-1,3-benzoxazol-2-yl)acetate
• CAS NO: 138420-09-4
• Molecular Formula: C11H10ClNO3
• Molecular Weight: 239.66
• Mol File: 138420-09-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(138420-09-4)
• EPA Substance Registry System: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(138420-09-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 138420-09-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with specific targets and mechanisms of action.
Used in Organic Synthesis:
In the field of organic synthesis, ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE is used as a building block for the creation of complex organic molecules. Its versatile chemical properties enable the formation of a wide range of compounds with different functionalities.
Used in Agrochemical Development:
ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE is utilized in the development of new agrochemicals, such as pesticides and herbicides. Its potential biological activities make it a valuable component in the design of effective and targeted agricultural chemicals.
Used in Chemical Compound Development:
As a starting material, ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE is employed in the development of new chemical compounds with specific properties and activities. Its unique structure and reactivity contribute to the creation of innovative materials with potential applications in various industries.

Upstream product

• 95-85-2 2-hydroxy-5-chloro-aniline 
• 352-23-8 ethyl 3,3,3-trifluoropropanoate 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 

Relevant articles and documents

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction

The β-catenin/T-cell factor (Tcf) protein-protein interaction (PPI) plays a critical role in the β-catenin signaling pathway which is hyperactivated in many cancers and fibroses. Based on compound 1, which was designed to target the Tcf4 G13ANDE17 binding site of β-catenin, extensive structure-activity relationship studies have been conducted. As a result, compounds 53 and 57 were found to disrupt the β-catenin/Tcf PPI with the Ki values of 0.64 and 0.44 μM, respectively, and exhibit good selectivity for β-catenin/Tcf over β-catenin/E-cadherin and β-catenin/adenomatous polyposis coli (APC) PPIs. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) cell viability assays revealed that 56, the ethyl ester of 53, was more potent than 53 in inhibiting viability of most of the Wnt/β-catenin hyperactive cancer cells. Further cell-based studies indicated that 56 disrupted the β-catenin/Tcf PPI without affecting the β-catenin/E-cadherin and β-catenin/APC PPIs, suppressed transactivation of Wnt/β-catenin signaling in dose-dependent manners, and inhibited migration and invasiveness of Wnt/β-catenin-dependent cancer cells.

Cs2CO3-promoted defluorination and functionalization of α-CF3 carbonyl compounds in the presence of: N -, O -, and/or S -nucleophiles

A simple, efficient, and mild method for defluorination and functionalization of 3,3,3-trifluoro carbonyl compounds has been developed. In the present method, Cs2CO3 can easily convert α-trifluoromethyl esters, amides, and ketones in

Monoazo or disazo pigments based on (benoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides

Water-insoluble azo colorants, their preparation and use The invention relates to monoazo and disazo compounds of the formula (I) STR1 in which D is the radical of a carbocyclic or heterocyclic diazo or bisdiazo component, R1 and R2, independently of one another, are each a substituted or unsubstituted aryl or heteroaryl radical, X1 and X2, independently of one another, are each ring-forming ether oxygen or a substituted or unsubstituted imide grouping and n has the value 0 or 1, in which rings A and B, independently of one another, can each be additionally substituted and/or carry substituted or unsubstituted fused rings. These new compounds of the formula (I) are obtained by coupling diazotized amines or diamines of the type D--NH2 or H2 N--D--NH2 with (benzoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides. Depending on the presence and length of alkyl chains, the compounds of the formula (I) are suitable for use as pigments, disperse dyes or oil-soluble dyes.