138420-09-4

Basic information

• Product Name: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE
• Synonyms: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE;Ethyl 2-(5-chloro-1,3-benzoxazol-2-yl)acetate;(5-Chloro-1,3-benzoxazol-2-yl)acetic acid ethyl ester, 5-Chloro-2-(2-ethoxy-2-oxoethyl)-1,3-benzoxazole;Ethyl (5-chloro-1,3-benzoxazol-2-yl)acetate
• CAS NO: 138420-09-4
• Molecular Formula: C11H10ClNO3
• Molecular Weight: 239.66
• Mol File: 138420-09-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(138420-09-4)
• EPA Substance Registry System: ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE(138420-09-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 138420-09-4(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE is a chemical compound with the molecular formula C11H9ClO3. It is a white crystalline solid that is commonly used in organic synthesis and pharmaceutical research. ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE belongs to the class of benzooxazoles, which are heterocyclic aromatic compounds containing a benzene ring fused with an oxazole ring. It has potential applications in the development of new drugs and agrochemicals due to its diverse biological activities.ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE may be used as a building block in the synthesis of other organic molecules or as a starting material for the development of new chemical compounds with specific properties and activities.

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Relevant articles and documents

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction

The β-catenin/T-cell factor (Tcf) protein-protein interaction (PPI) plays a critical role in the β-catenin signaling pathway which is hyperactivated in many cancers and fibroses. Based on compound 1, which was designed to target the Tcf4 G13ANDE17 binding site of β-catenin, extensive structure-activity relationship studies have been conducted. As a result, compounds 53 and 57 were found to disrupt the β-catenin/Tcf PPI with the Ki values of 0.64 and 0.44 μM, respectively, and exhibit good selectivity for β-catenin/Tcf over β-catenin/E-cadherin and β-catenin/adenomatous polyposis coli (APC) PPIs. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) cell viability assays revealed that 56, the ethyl ester of 53, was more potent than 53 in inhibiting viability of most of the Wnt/β-catenin hyperactive cancer cells. Further cell-based studies indicated that 56 disrupted the β-catenin/Tcf PPI without affecting the β-catenin/E-cadherin and β-catenin/APC PPIs, suppressed transactivation of Wnt/β-catenin signaling in dose-dependent manners, and inhibited migration and invasiveness of Wnt/β-catenin-dependent cancer cells.

Monoazo or disazo pigments based on (benoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides

Water-insoluble azo colorants, their preparation and use The invention relates to monoazo and disazo compounds of the formula (I) STR1 in which D is the radical of a carbocyclic or heterocyclic diazo or bisdiazo component, R1 and R2, independently of one another, are each a substituted or unsubstituted aryl or heteroaryl radical, X1 and X2, independently of one another, are each ring-forming ether oxygen or a substituted or unsubstituted imide grouping and n has the value 0 or 1, in which rings A and B, independently of one another, can each be additionally substituted and/or carry substituted or unsubstituted fused rings. These new compounds of the formula (I) are obtained by coupling diazotized amines or diamines of the type D--NH2 or H2 N--D--NH2 with (benzoxazol-2-yl)- or (benzimidazol-2-yl)-arylacetamides. Depending on the presence and length of alkyl chains, the compounds of the formula (I) are suitable for use as pigments, disperse dyes or oil-soluble dyes.