138428-37-2Relevant articles and documents
Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides
Lebel, Hélène,Mathieu, Gary,Patel, Heena
, p. 2157 - 2168 (2020/11/23)
The first continuous flow process was developed to synthesize N-methyl secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-methyl secondary amines were produced in good to excellent yields, including a number of bioactive compounds or their precursors. Up to 10.6 g (88% yield) of an N-methyl secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alcohol. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed.
Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors
Villa, Stefania,Legnani, Laura,Colombo, Diego,Gelain, Arianna,Lammi, Carmen,Bongiorno, Daniele,Ilboudo, Denise P.,McGee, Kellen E.,Bosch, Jürgen,Grazioso, Giovanni
, p. 473 - 486 (2018/02/06)
The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein–protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falc
2,4,6-trichloro phenylpyridine ethyl ether plant growth regulator
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Paragraph 0017; 0018; 0019, (2017/07/20)
The invention discloses a 2,4,6-trichloro phenylpyridine ethyl ether compound structurally shown as a formula I. The 2,4,6-trichloro phenylpyridine ethyl ether compound is used as a plant growth regulator. The compound shown as a formula I has the advantages that the plant rooting and sprouting are promoted, the growth and the development are promoted; the obvious yield improving effect is achieved; the structure is simple; the production and use cost is low; the use is safe; the compound can be used for crop and fruit and vegetable yield improvement and quality improvement. The formula I is shown as the accompanying drawing.