1384468-52-3

Basic information

• Product Name: benzyl (S)-3,3-dimethyl-2-nitromethyl-4-oxobutyrate
• Synonyms: benzyl (S)-3,3-dimethyl-2-nitromethyl-4-oxobutyrate
• CAS NO: 1384468-52-3
• Molecular Weight: 279.293
• Mol File: 1384468-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl (S)-3,3-dimethyl-2-nitromethyl-4-oxobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (S)-3,3-dimethyl-2-nitromethyl-4-oxobutyrate(1384468-52-3)
• EPA Substance Registry System: benzyl (S)-3,3-dimethyl-2-nitromethyl-4-oxobutyrate(1384468-52-3)

Safety Data

• Hazardous Substances Data: 1384468-52-3(Hazardous Substances Data)

Upstream product

• 78-84-2 isobutyraldehyde 

Downstream Products

• 1373232-20-2 (S)-4,4-dimethylpyrrolidine-3-carboxylic acid 
• 1384468-57-8 (S)-N-(2-nitrophenylsulfonyl)-4,4-dimethylpyrrolidine-3-carboxylic acid 
• 1384468-70-5 benzyl (S)-3-[1,3]dioxolan-2-yl-2-nitromethyl-3-methylbutyrate 

Relevant articles and documents

Enantioselective synthesis of gabapentin analogues via organocatalytic asymmetric Michael addition of α-branched aldehydes to β-nitroacrylates

Michael addition reaction of α-branched aldehydes to β-nitroacrylates was successfully carried out by using a mixed catalyst consisting of a primary amino acid, l-phenylalanine, and its lithium salt to give β-formyl-β′-nitroesters having a quaternary carbon centre in good yields (up to 85%) with high enantioselectivity (up to 98% ee). By using benzyl β-nitroacrylates as Michael acceptors, the obtained β-formyl-β′-nitroesters were converted into various 4,4-disubstituted pyrrolidine-3-carboxylic acids including analogues of gabapentin (Neurotin) in one step from the Michael adducts in high yields. The Royal Society of Chemistry 2012.