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Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[3,2-b]pyridine, 5-methoxy-3-methylis used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1H-Pyrrolo[3,2-b]pyridine, 5-methoxy-3-methylis employed as a building block for the preparation of bioactive molecules, facilitating the discovery and optimization of novel drug candidates with potential applications in treating various diseases and conditions.
Used in Organic Synthesis:
1H-Pyrrolo[3,2-b]pyridine, 5-methoxy-3-methylis utilized as a versatile synthetic building block in organic synthesis, enabling the creation of a diverse range of chemical compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 4744-08-5 1,1-diethoxypropane 
• 1338466-39-9 di-tert-butyl 1-(6-methoxypyridin-3-yl)hydrazine-1,2-dicarboxylate 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 111795-99-4 2-(6-methoxy-3-nitropyridin-2-yl)acetonitrile 
• 138469-68-8 2-(6-methoxy-3-nitropyridin-2-yl)propanenitrile 

Relevant academic research and scientific papers

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.

Two-step route to indoles and analogues from haloarenes: A variation on the Fischer indole synthesis

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange and quenching with di-tert-butyl azodicarboxylate, followed by reaction with aldehy

Synthesis of C3-substituted 4-azaindoles: An easy access to 4-azamelatonin and protected 4-azatryptophan

(Chemical Equation Presented) C3-Substituted-4-azaindoles were synthesized from pyridylacetonitriles in a two-step sequence allowing the easy introduction of a range of substituents. This strategy permits the rapid synthesis of 4-azamelatonin and a protec

THE USE OF o-MITROARYLACETONITRILES IN THE MITSUNOBU REACTION: MECHANISTIC IMPLICATIONS AND SYNTHETIC APPLICATIONS

o-Nitroarylacetonitriles (1) have been used as carbon acid participants in the Mitsunobu reaction to yield 2-(o-nitroaryl)-2-alkylacetonitriles (2).Reductive cyclization of 2 afforded 3-alkylindoles (3) in moderate yield.The use of o-nitroarylacetonitrile

THE USE OF o-NITROARYLACETONITRILES AS CARBON ACID PARTICIPANTS IN THE MITSUNOBU REACTION

The use of o-nitroarylacetonitriles as carbon acids in the Mitsunobu reaction is discussed as a method of carbon-carbon bond formation.This reaction represents a rare example of a carbon acid participating in a Mitsunobu reaction.