138472-01-2

Basic information

• Product Name: NOR-3
• Synonyms: NOR-3;4-ETHYL2-E-(HYDROXYIMINO)-5-NITRO-3E-HEXENAMIDE;FK409;(+/-)-(E)-ETHYL-2-[(E)-HYDROXYIMINO]-5-NITRO-3-HEXENEAMIDE;(+/-)-(E)-4-ETHYL-2-[(E)-HYDROXYIMINO]-5-NITRO-3-HEXENAMIDE
• CAS NO: 138472-01-2
• Molecular Formula: C8H13N3O4
• Molecular Weight: 215.21
• Mol File: 138472-01-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.2 °C at 760 mmHg
• Flash Point: 212.7 °C
• Appearance: /
• Density: 1.33 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: NOR-3(CAS DataBase Reference)
• NIST Chemistry Reference: NOR-3(138472-01-2)
• EPA Substance Registry System: NOR-3(138472-01-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 138472-01-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 138472-01-2 differently. You can refer to the following data:
1. FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. The IC50 for the inhibition of platelet aggregation is 4.9 μM.
2. NOR-3 is a cell-permeable NO donor.

Upstream product

• 63883-69-2 (E)-2-ethyl-2-butenal 
• 92454-24-5 (E,E)-4-ethyl-2,4-hexadienamide 

Relevant articles and documents

New reagents for controlled release of nitric oxide. Structure-stability relationships

The synthesis and structure-stability relationships of a series of novel FK409 derivatives are described. The rates of decomposition in aqueous solution (pH 8.0, 30°C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.

Nitro aliphatic compounds, process for preparation thereof and use thereof

New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.