1384849-55-1

Basic information

• Product Name: ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate
• Synonyms: ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate
• CAS NO: 1384849-55-1
• Molecular Weight: 307.7
• Mol File: 1384849-55-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate(1384849-55-1)
• EPA Substance Registry System: ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate(1384849-55-1)

Safety Data

• Hazardous Substances Data: 1384849-55-1(Hazardous Substances Data)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 1384849-62-0 3-(4-chlorobenzyl)amino-4,4,4-trifluorobutan-1-ol 
• 1384849-69-7 4-chloro-N-(4-chlorobenzyl)-1,1,1-trifluorobutan-2-amine 
• 1384849-76-6 1-(4-chlorobenzyl)-2-(trifluoromethyl)azetidine 
• 1384849-90-4 N-benzyl-N-(4-chlorobenzyl)-4-iodo-1,1,1-trifluorobutan-2-amine 
• 1384850-00-3 4-[N-(4-chlorobenzyl)-N-methylamino]-5,5,5-trifluoropentanenitrile 
• 1384850-04-7 N-(4-chlorobenzyl)-N-methyl-4-phenylthio-1,1,1-trifluorobutan-2-amine 

Relevant articles and documents

Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts

A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl) azetidines as a new class of constrained azaheterocycles was developed starting from ethyl 4,4,4-trifluoroacetoacetate via imination, hydride reduction, chlorination, and base-induced ring closure. Furthermore, the reactivity profile of these 2-CF3-azetidines was assessed by means of quaternization and subsequent regiospecific ring opening at C4 of the azetidinium intermediates by oxygen, nitrogen, carbon, sulfur, and halogen nucleophiles, pointing to a clear difference in reactivity compared to azetidines bearing other types of electron-withdrawing groups at C2.