138490-62-7

Basic information

• Product Name: 4-Methanesulfonylamino-N-{2-[methyl-(1-methyl-1H-benzoimidazol-2-yl)-amino]-ethyl}-benzenesulfonamide
• CAS NO: 138490-62-7
• Molecular Weight: 437.544
• Mol File: 138490-62-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Methanesulfonylamino-N-{2-[methyl-(1-methyl-1H-benzoimidazol-2-yl)-amino]-ethyl}-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methanesulfonylamino-N-{2-[methyl-(1-methyl-1H-benzoimidazol-2-yl)-amino]-ethyl}-benzenesulfonamide(138490-62-7)
• EPA Substance Registry System: 4-Methanesulfonylamino-N-{2-[methyl-(1-methyl-1H-benzoimidazol-2-yl)-amino]-ethyl}-benzenesulfonamide(138490-62-7)

Safety Data

• Hazardous Substances Data: 138490-62-7(Hazardous Substances Data)

Upstream product

• 49572-60-3 2-bromo-1-methyl-1H-benzo[d]imidazole 
• 54624-57-6 2-bromo-1H-1,3-benzodiazole 
• 134469-07-1 Benzimidazol-2-thiol 
• 93345-21-2 4-[(methylsulfonyl)amino]benzenesulfonyl chloride 

Relevant articles and documents

Class III Antiarrhythmic Activity of Novel Substituted 4-benzamides and Sulfonamides

The synthesis and Class III antiarrhythmic activity of a series of 4-benzamides and sulfonamides are described.Selected compounds shown a potent Class III activity and are devoid of effects on conduction both in vitro (dog Purkinje fibers) and in vivo (anesthetized dogs).Compounds having a 2-aminobenzimidazole group were found to be the most potent, and one compound having the heterocycle (5, WAY-123,398) was selected for further characterization.Compound 5 was shown to have good oral bioavailability and a favorable hemodynamic profile to produce a 3-fold increase of the ventricular fibrillation threshold and to terminate ventricular fibrillation, restoring sinus rhythm in anesthetized dogs.Voltage-clamp studies in isolated myocytes show that 5 is a potent and specific blocker of the delayed rectifier potassium current (IK) at concentrations that cause significant prolongation of action potential duration.