137863-17-3

Basic information

• Product Name: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester
• Synonyms: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester;L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methyl ester;N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl ester;Valsartan methyl ester;(S)-Methyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoat;Valsartan Related CoMpound E;(S)-Methyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)pentanaMido)-3-Methylbutanoate;(S)-methyl 2-(N-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate
• CAS NO: 137863-17-3
• Molecular Formula: C₂₅H₃₁N₅O₃
• Molecular Weight: 449.54534
• EINECS: 1308068-626-2
• Mol File: 137863-17-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 129-130℃
• Boiling Point: 647.716 °C at 760 mmHg
• Flash Point: 345.526 °C
• Appearance: /
• Density: 1.169±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester(137863-17-3)
• EPA Substance Registry System: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester(137863-17-3)

Safety Data

• Hazardous Substances Data: 137863-17-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 137863-17-3 differently. You can refer to the following data:
1. Valsartan Methyl Ester is an analog of Valsartan (V095750), is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
2. Valsartan Methyl Ester (Valsartan USP Related Compound E) is an analog of Valsartan (V095750), is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Upstream product

• 3839-22-3 2-cyanobenzoic acid 
• 67-56-1 methanol 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 400747-06-0 C₁₆H₁₃O₂N 
• 137863-89-9 N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester 
• 781664-81-1 N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester 
• 883223-10-7 N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 168265-56-3 1-benzyl-5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 
• 38612-13-4 4-bromobenzyl benzoate 
• 106-38-7 para-bromotoluene 
• 482577-59-3 N-((2'-cyano[1,1'-biphenyl]-4-yl)methyl)-L-valine methyl ester hydrochloride 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 6306-52-1 L-valine methylester hydrochloride 

Downstream Products

• 137862-53-4 valsartan 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 137862-62-5 (S)-N-(1-Hydroxymethyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine 
• 137862-87-4 valsartan 

Relevant articles and documents

Convenient synthesis of Valsartan via a Suzuki reaction

An efficient synthesis of the angiotensin II inhibitor Valsartan (Diovan) is presented. The formation of the aryl-aryl bond represents the key step of its synthesis, which has been done by a Suzuki coupling of aryl boronate with 2-bromophenyl oxazoline with good yield and purity. This method overcomes many of the drawbacks associated with the previously reported syntheses.

A facile synthesis of 5-(4'-substituted)-[1,1'-biphenyl]-2-yl)-1H-tetrazole: A key intermediate for synthesis of angiotensin II receptor antagonist

A convenient commercial scale synthesis of 5-(4'-(substituted)-[1,1'-biphenyl]-2-yl)-1H-tetrazole 1 a common intermediate for so many angiotensin II receptors antagonists, has been achieved with high purity using a simple synthetic protocol. The advantage

DEPROTECTION METHOD FOR TETRAZOLE COMPOUND

The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers. Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Br?nsted acid: wherein each symbol is as defined in the present specification.