Synthesis and Biological Evaluation of Dihydroeptastatin, a Novel Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

DOI: 10.1021/jm00096a015

Source and publish data:

Journal of Medicinal Chemistry p. 3388 - 3393 (1992)

Update date:2022-08-05

Topics:

Authors:

Bone, Elizabeth A.

Davidson, Alan H.

Lewis, Christopher N.

Todd, Richard S.

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Article abstract of DOI:10.1021/jm00096a015

The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastasin (7) is described.The key C-3 hydroxyl group is introduced via Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from

Full text of DOI:10.1021/jm00096a015

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