Journal of Medicinal Chemistry p. 3388 - 3393 (1992)
Update date:2022-08-05
Topics:
Bone, Elizabeth A.
Davidson, Alan H.
Lewis, Christopher N.
Todd, Richard S.
The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastasin (7) is described.The key C-3 hydroxyl group is introduced via Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from
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