Synthesis and Biological Evaluation of Dihydroeptastatin, a Novel Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

DOI: 10.1021/jm00096a015

Source and publish data:

Journal of Medicinal Chemistry p. 3388 - 3393 (1992)

Update date:2022-08-05

Topics:

Authors:

Bone, Elizabeth A.

Davidson, Alan H.

Lewis, Christopher N.

Todd, Richard S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00096a015

The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastasin (7) is described.The key C-3 hydroxyl group is introduced via Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from

Full text of DOI:10.1021/jm00096a015

Products guided by the article

Product name:dihydroeptastatin

Cas No:138505-91-6

R&D Labs maybe for 138505-91-6

QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED

Contact:+86-0532-82683616

Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
MS( MAOSHENG )Chemical CO.,LTD

Contact:+86-519-82726678.82726378

Address:TAOXI INDUSTRY ZONE JINTAN
Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Nanjing Fayekong Chemcial Co.,Ltd(expird)

Contact:86-25-58813444

Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809-

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park

Relevant to this article

Selenium Blue-α and -β: Turning on the fluorescence of a pyrenyl fluorophore via oxidative cleavage of the Se-C bond by reactive oxygen species

Doi:10.1016/j.tetlet.2012.05.022
(2012)
Organelle-specific detection of phosphatase activities with two-photon fluorogenic probes in cells and tissues

Doi:10.1021/ja3036256
(2012)
Transition Metal Catalyzed Radical Cyclization: New Preparative Route to γ-Lactams from Allylic Alcohols via the <3.3>-Sigmatropic Rearrangement of Allylic Trichloroacetimidates and the Subsequent Ruthenium-Catalyzed Cyclization of N-Allyltrichloroacetamides

Doi:10.1021/jo00032a016
(1992)
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Doi:10.3762/bjoc.8.111
(2012)
Palladium(ii)-catalysed total synthesis of naturally occurring pyrano[3,2-a]carbazole and pyrano[2,3-b]carbazole alkaloids

Doi:10.1039/c4ob00367e
(2014)
"Clicked" fluoropolymer elastomers as robust materials for potential microfluidic device applications

Doi:10.1039/c1jm14131g
(2012)

Article Doi