13856-88-7

Upstream product

• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 71-36-3 butan-1-ol 
• 106-39-8 bromochlorobenzene 
• 111-27-3 hexan-1-ol 
• 693-25-4 n-pentylmagnesium bromide 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 97492-92-7 Bernsteinsaeure-mono-<1-(4-chlor-phenyl)-hexylester> 
• 7295-50-3 1-(4-chlorophenyl)hexan-1-one 

Relevant academic research and scientific papers

CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES

The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

The combination of nickel metallaphotoredox catalysis, hydrogen atom transfer catalysis, and a Lewis acid activation mode, has led to the development of an arylation method for the selective functionalization of alcohol α-hydroxy C?H bonds. This approach employs zinc-mediated alcohol deprotonation to activate α-hydroxy C?H bonds while simultaneously suppressing C?O bond formation by inhibiting the formation of nickel alkoxide species. The use of Zn-based Lewis acids also deactivates other hydridic bonds such as α-amino and α-oxy C?H bonds. This approach facilitates rapid access to benzylic alcohols, an important motif in drug discovery. A 3-step synthesis of the drug Prozac exemplifies the utility of this new method.

Efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols

The efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols is described. In the presence of the commercially available iron catalyst (ferrocenecarboxaldehyde, 1b) and a catalytic amount of base, the reactions give β-alkylated higher alcohols in high yields in the absence of any sacrificial agents (hydrogen acceptors or hydrogen donors) and nitrogen or phosphorus ligands. For the first time, iron is employed as an inexpensive and environmentally benign alternative with high atom efficiency to noble metal-based catalysts in this type of reaction. Copyright

Direct β-alkylation of secondary alcohols with primary alcohols catalyzed by a Cp*Ir complex

(Chemical Equation Presented) A new catalytic system for β-alkylation of secondary alcohols has been developed. In the presence of [Cp*IrCl 2]2 (Cp* = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give β-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.