7295-50-3

Usage

Uses

Used in Chemical Industry:
1-Hexanone, 1-(4-chlorophenyl)is used as a solvent for its ability to dissolve a wide range of substances, which is essential in the manufacturing of paints, coatings, adhesives, and cleaning products. Its solubility properties make it a valuable component in these industries.
Used in Pharmaceutical Industry:
As a chemical intermediate, 1-Hexanone, 1-(4-chlorophenyl)plays a crucial role in the synthesis of various pharmaceuticals. Its reactivity and functional groups contribute to the production of a range of medicinal compounds.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, P4CP is utilized as a chemical intermediate for the development of products such as pesticides and herbicides, where its chemical properties are harnessed to create effective agricultural solutions.

Upstream product

• 142-61-0 Hexanoyl chloride 
• 108-90-7 chlorobenzene 
• 99-91-2 para-chloroacetophenone 
• 71-36-3 butan-1-ol 
• 17380-83-5 1-(4-chlorophenyl)cyclohexan-1-ol 
• 13856-88-7 1-(p-chlorophenyl)hexan-1-ol 
• 693-25-4 n-pentylmagnesium bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 104376-24-1 (E)-1-pentenylboronic acid 
• 106-39-8 bromochlorobenzene 
• 66-25-1 hexanal 
• 122-01-0 4-chloro-benzoyl chloride 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 21406-61-1 pentyltriphenylphosphonium bromide 

Downstream Products

• 38237-76-2 1-(4-aminophenyl)-hexan-1-one 
• 109248-56-8 Dipenty-<4-chlor-phenyl>-methan 
• 132104-25-7 -pentyl-<4-chlor-phenyl>-methan 
• 2001-08-3 2-bromo-1-(4-chlorophenyl)hexan-1-one 
• 107680-27-3 (2R,3R)-2-(4-Chloro-phenyl)-3-[1,2,4]triazol-1-ylmethyl-heptane-2,3-diol 
• 107680-26-2 (2R,3S)-2-(4-Chloro-phenyl)-3-[1,2,4]triazol-1-ylmethyl-heptane-2,3-diol 
• 94147-62-3 1-(4-Chloro-phenyl)-2-hydroxy-2-[1,2,4]triazol-1-ylmethyl-hexan-1-one 
• 93004-07-0 α-<4-Chlor-phenyl>-hexylamin 
• 91768-09-1 1,1-Dichlor-1-(4-chlor-phenyl)-hexan 
• 109249-68-5 Dipentyl-<4-chlor-phenyl>-carbinol 

Relevant academic research and scientific papers

Preparation method of aryl ketone compound

The invention provides a preparation method of an aryl ketone compound, and belongs to the technical field of compound synthesis. The method comprises the following steps: under the action of a silver catalyst and water, carrying out reaction on aryl alkyne with a structure as shown in a formula 1 in a solvent at 60-120 DEG C for 12-48 hours, and separating and purifying a product after the reaction is finished, so as to obtain the single aryl ketone compound with a structure as shown in a formula I, the raw materials are easy to obtain, the experimental operation is simple, the yield of the prepared single aryl ketone compound is good, and gram-scale experiments can be carried out.

Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols

An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.

CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES

The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

Gram-Positive and Gram-Negative Antibiotic Activity of Asymmetric and Monomeric Robenidine Analogues

Desymmetrisation of robenidine (1: N′,2-bis((E)-4-chlorobenzylidene)hydrazine-1-carboximidhydrazide) and the introduction of imine alkyl substituents gave good antibiotic activity. Of note was the increased potency of two analogues against vancomycin-resistant Enterococci (VRE), one of which returned a MIC of 0.5 μg mL?1. Five analogues were found to be equipotent or more potent than the lead 1. Introduction of an indole moiety resulted in the most active robenidine analogue against methicillin-resistant S. aureus (MRSA), with a MIC of 1.0 μg mL?1. Imine C=NH isosteres (C=O/C=S) were inactive. Monomeric analogues were 16–64 μg mL?1 active against MRSA and VRE. An analogue that lacks the terminal hydrazide NH moiety showed modest Gram-negative activity at 64 μg mL?1. A 4-tert-butyl analogue was shown to be active against both Gram-positive and -negative strains at 16–64 μg mL?1. In general, additional modifications with aromatic moieties was poorly tolerated, except with concomitant introduction of an imine C-alkyl group. The activity of these analogues against MRSA and VRE ranged from 8 μg mL?1 to inactive (MIC>128 μg mL?1) with the naphthyl and indole analogues. Gram-negative activity was most promising with two compounds at 16 μg mL?1 against E. coli. Against P. aeruginosa, the highest activity observed was with MIC values of 32 μg mL?1 with another two analogues. Combined, these findings support the further development of the (E)-2-benzylidenehydrazine-1-carboximidamide scaffold as a promising scaffold for the development of antibiotics against Gram-positive and Gram-negative strains.

An Efficient α-alkylation of aromatic ketones with primary alcohols catalyzed by [cp*ircl2]2 without solvent

Aromatic ketones are directly alkylated at α position with primary alcohols at 110°C in the presence of catalytic amount of KOH and [Cp*IrCl2]2 (Cp=pentamethylcyclopentadienyl) catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes. Copyright

Rhodium-catalyzed reaction of 1-alkenylboronates with aldehydes leading to allylation products

Synthetic equivalents: 1-Alkenylboronates perform the role of an allylating reagent. Their reaction with aldehydes in the presence of a cationic rhodium(I)/dppm catalyst results in a highly diastereoselective production of anti-configured homoallylic alco

Direct acylation of aryl bromides with aldehydes by palladium catalysis

A new protocol for the direct acylation of aryl bromides with aldehydes is established. It appears to involve palladium-amine cooperative catalysis, affording synthetically important alkyl aryl ketones in moderate to excellent yields in a straightforward manner, and broadening the scope of metal-catalyzed coupling reactions. Copyright

Ir- and Ru-catalyzed sequential reactions: Asymmetric α-alkylative reduction of ketones with alcohols

(Chemical Equation Presented) The compatibility between [{IrCl(cod)} 2] and ruthenium complex 1 to achieve asymmetric α-alkylative reduction of prochiral ketones with primary alcohols is an essential factor in obtaining optically active alcohols with elongation of the carbon skeleton in good yields with a high enantioselectivity.

Direct β-alkylation of secondary alcohols with primary alcohols catalyzed by a Cp*Ir complex

(Chemical Equation Presented) A new catalytic system for β-alkylation of secondary alcohols has been developed. In the presence of [Cp*IrCl 2]2 (Cp* = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give β-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.

Direct conversion of N-methoxy-N-methylamides (Weinreb amides) to ketones via a nonclassical Wittig reaction

(Chemical Equation Presented) N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product.