138585-08-7

Basic information

• Product Name: 4-(tert-Butyldimethylsiloxy)benzyl alcohol
• Synonyms: 4-(tert-Butyldimethylsiloxy)benzyl alcohol;4-(tert-Butyldimethylsiloxy)benzenemethanol;4-(tert-Butyldimethylsilyloxy)benzenemethanol;4-(tert-Butyldimethylsilyloxy)benzyl alcohol;4-[(tert-Butyldimethylsilyl)oxy]benzenemethanol;[4-(tert-Butyl-diMethyl-silanyloxy)phenyl]-Methanol
• CAS NO: 138585-08-7
• Molecular Formula: C₁₃H₂₂O₂Si
• Molecular Weight: 238.4
• Mol File: 138585-08-7.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 288.4±23.0 °C(Predicted)
• Appearance: /
• Density: 0.970±0.06 g/cm3(Predicted)
• PKA: 14.55±0.10(Predicted)
• CAS DataBase Reference: 4-(tert-Butyldimethylsiloxy)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-Butyldimethylsiloxy)benzyl alcohol(138585-08-7)
• EPA Substance Registry System: 4-(tert-Butyldimethylsiloxy)benzyl alcohol(138585-08-7)

Safety Data

• Hazardous Substances Data: 138585-08-7(Hazardous Substances Data)

Usage

General Description

4-(tert-Butyldimethylsiloxy)benzyl alcohol is a chemical compound with the molecular formula C14H24O2Si. It is commonly used as a reagent in organic synthesis, particularly in the formation of silicon-containing organic compounds. 4-(tert-Butyldimethylsiloxy)benzyl alcohol is a benzyl alcohol derivative that features a tert-butyldimethylsiloxy group attached to the benzene ring. It is a clear, colorless liquid at room temperature and is insoluble in water but soluble in organic solvents such as ether and chloroform. 4-(tert-Butyldimethylsiloxy)benzyl alcohol is widely used in the pharmaceutical and cosmetic industries as a versatile building block for the synthesis of novel compounds with potential biological and chemical properties.

Upstream product

• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 288-32-4 1H-imidazole 
• 589-29-7 p-xylylene glycol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 99-96-7 4-hydroxy-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 133642-20-3 4-(tert-butyldimethylsilanyloxy)benzoic acid methyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 83405-98-5 4-(tert-butyl-dimethylsilanyloxy)-benzoic acid 
• 117635-46-8 1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene 
• 249284-23-9 4-tert-butyl-butyldimethylsilyloxybenzyl alcohol THP ether 

Downstream Products

• 156878-45-4 4-<(tert-Butyldimethylsilyl)oxy>benzyl trifluoroacetate 
• 120506-39-0 (4-(bromomethyl)phenoxy) (tert-butyl) dimethylsilane 
• 245076-33-9 4-(t-butyldimethylsilyloxy)-α-thioacetyl-toluene 
• 249284-23-9 4-tert-butyl-butyldimethylsilyloxybenzyl alcohol THP ether 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 138585-09-8 4-(tert-butyldimethylsilyloxy)benzyl chloride 
• 250602-92-7 N-[4-(tert-butyldimethylsilyloxy)benzyloxy]phtalimide 
• 1391092-01-5 (4-(azidomethyl)phenoxy)(tert-butyl)dimethylsilane 
• 1253911-09-9 4-((prop-2-yn-1-yloxy)methyl)phenol 

Relevant articles and documents

Cyclic Diaryl λ3-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions

Biaryls have widespread applications in organic synthesis. However, sequentially polysubstituted biaryls are underdeveloped due to their challenging preparation. Herein, we report the synthesis of dissymetric 2,3,2′,3′,4-substituted biaryls via pericyclic reactions of cyclic diaryl λ3-bromanes. The functional groups tolerance and atom economy allow access to molecular complexity in a single reaction step. Continuous flow protocol has been designed for the scale-up of the reaction, while postfunctionalizations have been developed taking advantage of the residual Br-atom.

PROBE FOR DETECTING CARBAPENEM-RESISTANT BACTERIA AND USE THEREOF

The present disclosure relates to a compound represented by Chemical Formula 1, a probe for detecting antibiotic-resistant bacteria, which includes the compound, a composition containing the compound, a kit including the compound and a method for detectin

Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives

Multi-drug resistant tuberculosis (MDR-TB) represents a growing problem for global healthcare systems. In addition to 1.3 million deaths in 2018, the World Health Organisation reported 484,000 new cases of MDR-TB. Isoniazid is a key anti-TB drug that inhibits InhA, a crucial enzyme in the cell wall biosynthesis pathway and identical in Mycobacterium tuberculosis and M. bovis. Isoniazid is a pro-drug which requires activation by the enzyme KatG, mutations in KatG prevent activation and confer INH-resistance. ‘Direct inhibitors’ of InhA are attractive as they would circumvent the main clinically observed resistance mechanisms. A library of new 1,5-triazoles, designed to mimic the structures of both triclosan molecules uniquely bound to InhA have been synthesised. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with 2 (5-chloro-2-(4-(5-(((4-(4-chloro-2-hydroxyphenoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) exhibiting an IC50 of 5.6 μM. Whole-cell evaluation was also performed, with 11 (5-chloro-2-(4-(5-(((4-(cyclopropylmethoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) showing the greatest potency, with an MIC99 of 12.9 μM against M. bovis.