138624-40-5Relevant academic research and scientific papers
Radical alkylation of: Para -quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis
Wu, Qing-Yan,Min, Qing-Qiang,Ao, Gui-Zhen,Liu, Feng
supporting information, p. 6391 - 6394 (2018/09/25)
A novel photocatalytic protocol is herein described for the preparation of functionalized phenols via radical alkylation of para-quinone methides under transition-metal-free conditions. The reaction is external oxidant free and performed at ambient temperature upon visible light irradiation, allowing the access to various desired products in satisfactory yields. The readily available 4-alkyl-1,4-dihydropyridines serve as the effective alkyl radical precursors.
Alkyl transfer from C-C cleavage
Li, Guangxun,Chen, Rong,Wu, Lei,Fu, Qingquan,Zhang, Xiaomei,Tang, Zhuo
supporting information, p. 8432 - 8436 (2013/09/02)
Hydrogenation was only the beginning: Hantzsch esters have now been used to transfer alkyl groups to imines under mild catalytic conditions to provide a variety of amines (see scheme). Benzyl, secondary alkyl, and tertiary alkyl groups containing ether, ester, and hydroxy functionalities were transferred successfully. The use of Hantzsch esters as alkylation reagents offers a practical and complementary alternative to organometallic processes. Copyright
Novel syntheses of heterocycles with N-(1-haloalkyl)azinium halides. Part 2. Preparation of N-unsubstituted 1,4-dihydropyridines
Vanden Eynde,D'Orazio,Mayence,Maquestiau,Anders
, p. 1263 - 1268 (2007/10/02)
N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and aldehydes, readily react with enaminocarbonyl derivatives to yield 1,4-dihydropyridines under mild and neutral conditions.
