111259-61-1Relevant articles and documents
Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles
Jiang, Pengxing,Liu, Li,Tan, Jiajing,Du, Hongguang
supporting information, p. 4487 - 4491 (2021/05/31)
Herein we report a protocol for the visible-light-mediated alkylation/acylation reaction of benzothiazoles. Alkyl/acyl substituted Hantzsch esters are easily prepared and rationally used as radical precursors. In the presence of BF3·Et2O and Na2S2O8, various benzothiazole derivatives were readily obtained in good yields. Our user-friendly protocol can proceed by simple irradiation with blue LEDs (λ = 465 nm) and without the assistance of external photocatalysts. The reaction is also characterized by mild conditions and scalability, thus offering an alternative and efficient tool for the synthesis of 2-functionalized benzothiazoles.
Iron-Catalyzed Aerobic Oxidation of (Alkyl)(aryl)azinylmethanes
Sterckx, Hans,Sambiagio, Carlo,Lemière, Filip,Tehrani, Kourosch Abbaspour,Maes, Bert U. W.
supporting information, p. 1564 - 1570 (2017/08/11)
An iron-catalyzed aerobic oxidation of (alkyl)(aryl)azinylmethanes has been developed leading to tertiary alcohols in moderate to good yields. Hock rearrangement was identified as a major side reaction leading to a complex mixture of undesired products. Addition of thiourea sometimes allows inhibiting this side reaction and steers the reaction towards the desired products.
Copper-catalyzed direct benzylation or allylation of 1,3-azoles with N -tosylhydrazones
Zhao, Xia,Wu, Guojiao,Zhang, Yan,Wang, Jianbo
, p. 3296 - 3299 (2011/04/24)
Cu-Catalyzed cross-coupling of N-tosylhydrazones with 1,3-azoles leads to the direct C-H benzylation or allylation. Cu carbene migratory insertion is proposed to play the key role in this transformation.
