138630-78-1

Basic information

• Product Name: 4-(3-methoxy-11H-benzofluoren-11-yl)phenol
• Synonyms: 4-(3-methoxy-11H-benzofluoren-11-yl)phenol
• CAS NO: 138630-78-1
• Molecular Weight: 338.406
• Mol File: 138630-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(3-methoxy-11H-benzofluoren-11-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methoxy-11H-benzofluoren-11-yl)phenol(138630-78-1)
• EPA Substance Registry System: 4-(3-methoxy-11H-benzofluoren-11-yl)phenol(138630-78-1)

Upstream product

• 138630-73-6 <3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl>(4-hydroxyphenyl)methanone 
• 156641-98-4 (6-methoxy-2-naphthalene)boronic acid 
• 4181-97-9 phenyl 4-methoxybenzoate 
• 138630-69-0 3,4-dihydro-6-methoxy-1-(4-methoxybenzoyl)-2-naphthalenyl diphenyl phosphoric acid ester 
• 138630-70-3 (3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)-(4-methoxyphenyl)methanone 
• 138630-68-9 3,4-Dihydro-6-methoxy-1-(4-methoxybenzoyl)-2(1H)-naphthalenone 

Downstream Products

• 145410-91-9 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3-ol 
• 138630-80-5 3-methoxy-11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluorene 

Relevant articles and documents

TfOH-Catalyzed Intramolecular Annulation of 2-(Aryl)-Phenyl-Substituted p-Quinone Methides under Continuous Flow: Total Syntheses of Selaginpulvilin i and Isoselagintamarlin A

In this article, we describe a convenient method to access 9-aryl fluorene derivatives through a TfOH-catalyzed intramolecular 1,6-conjugate arylation of 2-(aryl)-phenyl-substituted p-quinone methides (QMs) under continuous flow using the microreaction technique. This method was found to be very effective for most of the p-QMs, and the corresponding 9-aryl fluorene derivatives were obtained in moderate to excellent yields. Moreover, this protocol was further elaborated to the first total syntheses of selaginpulvilin I and isoselagintamarlin A.

Benzo[a]fluorene compounds

Benzo[a]fluorenes having an aminoalkoxy group on a phenyl ring at the 11-position have estrogenic and anti-estrogenic activity.