138630-79-2

Upstream product

• 138630-73-6 <3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl>(4-hydroxyphenyl)methanone 
• 4181-97-9 phenyl 4-methoxybenzoate 
• 138630-68-9 3,4-Dihydro-6-methoxy-1-(4-methoxybenzoyl)-2(1H)-naphthalenone 
• 138630-70-3 (3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)-(4-methoxyphenyl)methanone 
• 138630-69-0 3,4-dihydro-6-methoxy-1-(4-methoxybenzoyl)-2-naphthalenyl diphenyl phosphoric acid ester 
• 156641-98-4 (6-methoxy-2-naphthalene)boronic acid 

Downstream Products

• 138630-67-8 11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluoren-3,9-diol 
• 138630-81-6 3,9-dimethoxy-11-<4-<2-(1-piperidinyl)ethoxy>phenyl>-11H-benzofluorene 

Relevant academic research and scientific papers

TfOH-Catalyzed Intramolecular Annulation of 2-(Aryl)-Phenyl-Substituted p-Quinone Methides under Continuous Flow: Total Syntheses of Selaginpulvilin i and Isoselagintamarlin A

In this article, we describe a convenient method to access 9-aryl fluorene derivatives through a TfOH-catalyzed intramolecular 1,6-conjugate arylation of 2-(aryl)-phenyl-substituted p-quinone methides (QMs) under continuous flow using the microreaction technique. This method was found to be very effective for most of the p-QMs, and the corresponding 9-aryl fluorene derivatives were obtained in moderate to excellent yields. Moreover, this protocol was further elaborated to the first total syntheses of selaginpulvilin I and isoselagintamarlin A.

Benzo[a]fluorene compounds

Benzo[a]fluorenes having an aminoalkoxy group on a phenyl ring at the 11-position have estrogenic and anti-estrogenic activity.

Antiestrogens. 3. Estrogen Receptor Affinities and Antiproliferative Effects in MCF-7 Cells of Phenolic Analogues of Trioxifene, phenyl>methanone

Benzothiophenes 3 and 4, derived from the acrylophenone antiestrogen trioxifene (2), are characterized by high estrogen receptor (ER) affinity and low residual estrogenicity compared to tamoxifen (1a).In order to characterize further the growth supperessi