138688-20-7Relevant academic research and scientific papers
Convenient syntheses of isomaltose derivatives from amygdalin
Chwalek, Martin,Plé, Karen
, p. 4749 - 4753 (2004)
The isomaltose trichloroacetimidate 7 was synthesized in five steps from D-amygdalin. The key step in this series of reactions was the acid catalyzed rearrangement of the inter-glycosydic bond to give the thermodynamically more stable α-anomer. The reacti
Immunomodulating beta-1,6-D-glucans
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Page/Page column 75, (2019/05/09)
This invention relates to modifications of β-1,6-D-glucans, e.g., structures according to Formula (I), and the ability of these compositions to modulate an immune response.
Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: Total synthesis and structure activity relationships
Richardson, Mark B.,Torigoe, Shota,Yamasaki, Sho,Williams, Spencer J.
supporting information, p. 15027 - 15030 (2015/10/12)
Mycobacterium tuberculosis H37Ra produces a range of immunogenic β-gentiobiosyl diacylglycerides. We report the total synthesis of several candidate structures and show that these compounds signal weakly through mouse, but not human, Mincle. Structure-activity relationships reveal a striking dependence upon acyl chain length for gentiobiosyl diacylglyceride signalling through Mincle. Significantly, a truncated β-glucosyl diglyceride was shown to provide potent signalling through both human and mouse Mincle and could activate murine bone marrow derived dendritic cells.
Synthesis and hemolytic activity of some hederagenin diglycosides
Chwalek, Martin,Ple, Karen,Voutquenne-Nazabadioko, Laurence
, p. 965 - 971 (2007/10/03)
Glycosylation of hederagenin with the trichloroacetimidate derivatives of six commercial disaccharides (D-cellobiose, D-lactose, D-maltose, D-melibiose, D-gentiobiose, D-isomaltose) was performed giving the protected saponins in high yields. Deprotection
