1386992-24-0Relevant academic research and scientific papers
A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam
Baglai, Iaroslav,Leeman, Michel,Kellogg, Richard M.,Noorduin, Willem L.
supporting information, p. 35 - 38 (2019/01/04)
A simple route to enantiomerically pure (S)-2-aminobutyramide-the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.
A process for preparing 2 - amino ding amide hydrochloride
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Paragraph 0024-0026, (2018/03/01)
The invention discloses a method for preparing 2-aminobutanamide hydrochloride. The method comprises the following steps of: reacting 2-aminobutyronitrile with aromatic aldehyde in an alkaline aqueous solution to generate corresponding Schiff base; and hydrolyzing the obtained Schiff base under an acidic condition to obtain 2-aminobutanamide hydrochloride. According to the method disclosed by the invention, the product quality is good, the method is simple to operate, the aftertreatment is convenient, and the process is environment-friendly and is beneficial to industrial production.
Process for the resolution of aminobutyramide
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Page/Page column 5, (2012/12/13)
The present invention relates to a process for the resolution of Schiff bases of racemic (R,S)-2-aminobutyramide to give optically pure (S)-2-aminobutyramide, an intermediate in the synthesis of levetiracetam.
