89603-48-5

Usage

Uses

Used in Pharmaceutical Industry:
Butanamide, 2-amino-, monohydrochloride is used as an antiarrhythmic agent for regulating abnormal heart rhythms. Its ability to modify the propagation of action potentials in the heart makes it a potential candidate for treating cardiac arrhythmias.
Used in Research and Development:
Butanamide, 2-amino-, monohydrochloride is used in research for its potential applications in treating cardiac arrhythmias and for its effects on the central nervous system. Further research and clinical trials are necessary to fully understand its potential applications and safety profile.

Upstream product

• 40651-89-6 2-aminobutyronitrile 
• 51376-79-5 α-aminobutyramide hydrobromide 
• 1386992-24-0 (±)-2‐((benzylidene)amino)butanamide 

Downstream Products

• 2623-91-8 (R)-2-aminobutyric acid 
• 80-60-4 D-α-amino-n-butyric acid 
• 1386992-24-0 (±)-2‐((benzylidene)amino)butanamide 

Relevant academic research and scientific papers

Preparation method of L-2-aminobutanamide hydrochloride

The invention relates to the technical field of preparation of chiral drug intermediates, and discloses a preparation method of L-2-aminobutanamide hydrochloride, which comprises the following steps: dropwise adding ethyl 2-bromobutyrate into stronger ammonia water, and carrying out chemical reaction in a closed container to prepare a prefabricated mixture; According to the preparation method of the L-2-aminobutanamide hydrochloride, ethyl 2-bromobutyrate is used as an initial raw material, and the medical intermediate L-2-aminobutanamide hydrochloride is prepared through ammonolysis and chiral resolution. Compared with the traditional preparation method, the preparation method adopts a chiral reagent (+)-mandelic acid with low raw material price and racemic 2-aminobutanamide hydrochloride to form diastereoisomers, the L-2-aminobutanamide hydrochloride is obtained through resolution by utilizing the difference of the dissolving properties of the diastereoisomers in ethanol, the optical purity and the chemical purity of the product are high, and the technical scheme has the advantages of mild reaction conditions, short reaction steps, high yield, stable product quality and easy realization of industrial production.

A process for preparing 2 - amino ding amide hydrochloride

The invention discloses a method for preparing 2-aminobutanamide hydrochloride. The method comprises the following steps of: reacting 2-aminobutyronitrile with aromatic aldehyde in an alkaline aqueous solution to generate corresponding Schiff base; and hydrolyzing the obtained Schiff base under an acidic condition to obtain 2-aminobutanamide hydrochloride. According to the method disclosed by the invention, the product quality is good, the method is simple to operate, the aftertreatment is convenient, and the process is environment-friendly and is beneficial to industrial production.

CONVERSION OF α-AMINONITRILES TO AMIDES BY A NEW PINNER TYPE REACTION

α-Aminonitriles were converted exclusively to the amides by 2-mercaptoethanol in anhydrous THF at -78 deg C by bubbling dry HCl gas.

Hydrolysis of various nitrile compounds to the amides by catalysis of 2-mercaptoethanol in a phosphate buffer

α-Aminonitriles, 4-nitrobenzonitrile and 3,5-dinitrobenzonitrile were hydrolyzed exclusively to amides efficiently when they were stirred with 2-mercaptoethanol in a phosphate buffer (pH 7.0, 50 mM).