89603-48-5

Basic information

• Product Name: Butanamide, 2-amino-, monohydrochloride
• CAS NO: 89603-48-5
• Molecular Formula: C4H10N2O.ClH
• Molecular Weight: 138.597
• Mol File: 89603-48-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-amino-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-amino-, monohydrochloride(89603-48-5)
• EPA Substance Registry System: Butanamide, 2-amino-, monohydrochloride(89603-48-5)

Safety Data

• Hazardous Substances Data: 89603-48-5(Hazardous Substances Data)

Usage

General Description

Butanamide, 2-amino-, monohydrochloride is a chemical compound classified as an amide derivative. It is also known by the trade name Fenyramidol. Butanamide, 2-amino-, monohydrochloride has been used as an antiarrhythmic agent, which means it has the ability to regulate abnormal heart rhythms. As a monohydrochloride, it is a salt form of the compound, with the addition of a hydrochloride group making it more water-soluble and thus more readily absorbed by the body. It has been researched for its potential use in treating cardiac arrhythmias, as well as for its effects on the central nervous system. Additionally, it is sometimes used to modify the propagation of action potentials in the heart. However, further research and clinical trials are necessary to fully understand its potential applications and safety profile.

Upstream product

• 51376-79-5 α-aminobutyramide hydrobromide 
• 1386992-24-0 (±)-2‐((benzylidene)amino)butanamide 
• 40651-89-6 2-aminobutyronitrile 

Downstream Products

• 1386992-24-0 (±)-2‐((benzylidene)amino)butanamide 
• 80-60-4 D-α-amino-n-butyric acid 
• 2623-91-8 (R)-2-aminobutyric acid 

Relevant articles and documents

Preparation method of L-2-aminobutanamide hydrochloride

The invention relates to the technical field of preparation of chiral drug intermediates, and discloses a preparation method of L-2-aminobutanamide hydrochloride, which comprises the following steps: dropwise adding ethyl 2-bromobutyrate into stronger ammonia water, and carrying out chemical reaction in a closed container to prepare a prefabricated mixture; According to the preparation method of the L-2-aminobutanamide hydrochloride, ethyl 2-bromobutyrate is used as an initial raw material, and the medical intermediate L-2-aminobutanamide hydrochloride is prepared through ammonolysis and chiral resolution. Compared with the traditional preparation method, the preparation method adopts a chiral reagent (+)-mandelic acid with low raw material price and racemic 2-aminobutanamide hydrochloride to form diastereoisomers, the L-2-aminobutanamide hydrochloride is obtained through resolution by utilizing the difference of the dissolving properties of the diastereoisomers in ethanol, the optical purity and the chemical purity of the product are high, and the technical scheme has the advantages of mild reaction conditions, short reaction steps, high yield, stable product quality and easy realization of industrial production.

CONVERSION OF α-AMINONITRILES TO AMIDES BY A NEW PINNER TYPE REACTION

α-Aminonitriles were converted exclusively to the amides by 2-mercaptoethanol in anhydrous THF at -78 deg C by bubbling dry HCl gas.