138702-88-2

Upstream product

• 100-52-7 benzaldehyde 
• 137618-21-4 1,3-dipropionyl-trans-4,5-diphenylimidazolidin-2-one 
• 138808-81-8 (R,R)-(-)-1,3-dipropionyl-trans-4,5-diphenylimidazolidin-2-one 
• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 

Downstream Products

• 7087-77-6 (1R,2S)-2-methyl-1-phenyl-propane-1,3-diol 
• 134731-67-2 (R,R)-trans-4,5-diphenylimidazolidin-2-one 
• 76549-04-7 (2R,3R)-(+)-3-hydroxy-2-methyl-3-phenylpropanoic acid 

Relevant academic research and scientific papers

Bifunctional chiral auxiliaries 3: Synthesis of homochiral 1,3-diols via asymmetric aldol reactions of dialkylboron enolates of 1,3-dipropionyl-trans-4,5-diphenyl-imidazolidin-2-one and aldehydes

Dibutylboron enolates derived from both racemic and homochiral 1,3-dipropionyl-trans-4,5-diphenylimidazolidin-2-one 3 react with aldehydes in highly diastereoselective dialdol reactions to give, after reductive cleavage of the acyl sidechain, substituted 1,3 diols.

Bifunctional chiral auxiliaries 7: Aldol reactions of enolates derived from 1,3-diacylimidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones

Dibutylboron enolates of 1,3-diacylimidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones undergo highly syn-stereoselective aldol reactions with aldehydes to allow elaboration of both acyl sidechains. The reaction is proposed to occur via sequential e