138740-54-2Relevant academic research and scientific papers
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]-octane as potent agonists for the α7 nicotinic acetylcholine receptor
Tatsumi, Ryo,Seio, Kohji,Fujio, Masakazu,Katayama, Jiro,Horikawa, Takashi,Hashimoto, Kenji,Tanaka, Hiroshi
, p. 3781 - 3784 (2004)
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the α7 nicotinic acetylcholine (α7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the α7 receptor.
New convergent one pot synthesis of amino benzyl ethers bearing a nitrogen-containing bicycle
López, Jhon J.,Pérez, Edwin G.
, p. 715 - 723 (2019/02/19)
We report herein a new convergent one pot method for the synthesis of amino benzyl ethers containing a bicyclic amine, derived from different substituted benzyl alcohols and bicyclic amino alcohols such as tropine, pseudotropine, and 3-quinuclidinol, using chlorotrimethylsilane and sodium iodide. In order to avoid the competitive reaction with the nitrogen atom, a solution of the separately prepared alkoxide of tropine, pseudotropine, and 3-quinuclidinol was added to the preformed substituted benzyl iodides and allowed to reflux at 90 °C for 15 h under nitrogen atmosphere. This method provides an efficient alternative of the preparation of amino benzyl ethers in organic synthesis with good yields in comparison with existed methods.
HETEROCYCLIC DERIVATIVES AS M3 MUSCARINIC RECEPTORS
-
Page/Page column 80, (2008/12/08)
This invention relates to M3 antagonists of formula (I) wherein R2, R4, R5, R6, W, V, A, D, X, t, u and v are as defined herein; pharmaceutical compositions containing them; methods for their preparation; and their use in the treatment of diseases where enhanced M3 receptor activation is implicated.
