138775-02-7

Basic information

• Product Name: (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID
• Synonyms: REF DUPL: (R)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid;(2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid;(R)-1-N-BOC-4-N-Cbz-piperazine-2-carboxylic acid;(2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester;1,2,4-Piperazinetricarboxylic acid, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
• CAS NO: 138775-02-7
• Molecular Formula: C₁₈H₂₄N₂O₆
• Molecular Weight: 364.396
• Mol File: 138775-02-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 518.9°Cat760mmHg
• Flash Point: 267.6°C
• Appearance: /
• Density: 1.272
• Vapor Pressure: 1.36E-11mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID(138775-02-7)
• EPA Substance Registry System: (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID(138775-02-7)

Safety Data

• Hazardous Substances Data: 138775-02-7(Hazardous Substances Data)

Usage

General Description

(R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID is a chemical compound with the molecular formula C15H22N4O4. It is a derivative of piperazine and contains both a BOC (t-butoxycarbonyl) and a CBZ (carboxybenzyl) protecting group, making it useful in organic synthesis as a protecting group for amines. (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID is often used in the pharmaceutical industry for the synthesis of various drugs, as well as in research and development of new chemical entities. It is important in the field of medicinal chemistry for its potential therapeutic applications and as a building block for the synthesis of more complex molecules.

InChI:InChI=1/C18H24N2O6/c1-18(2,3)26-17(24)20-10-9-19(11-14(20)15(21)22)16(23)25-12-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,21,22)/t14-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 501-53-1 benzyl chloroformate 
• 276695-09-1 (R)-4-carbobenzyloxypiperazine-2-carboxylic acid 

Downstream Products

• 930782-89-1 (R)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 
• 405175-79-3 (R)-4-((benzyloxy)carbonyl)piperazine-2-carboxylic acid 
• 1211400-32-6 (8aR)-N-(2,3-dichlorophenyl)-1,3-dioxo-2-[(1R,2S)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide 
• 1351165-31-5 C₂₂H₂₅N₃O₃ 
• 1351165-23-5 C₂₂H₂₅N₃O₃ 
• 1211400-33-7 (8aR)-N-(2,3-dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide 
• 1351165-63-3 C₂₁H₂₂Cl₂N₄O₂ 
• 1351165-30-4 C₂₁H₂₂Cl₂N₄O₂ 

Relevant articles and documents

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzym

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.