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138775-03-8

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138775-03-8 Usage

General Description

(S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid is a chemical compound that is used in the pharmaceutical industry. It is a derivative of piperazine, a heterocyclic organic compound that is widely used as a building block for various drugs. The "(S)" designation indicates that it is a stereoisomer, meaning it has a specific spatial arrangement of its atoms. The compound contains Boc and Cbz protecting groups, which are often used in organic synthesis to protect functional groups from unwanted reactions. The carboxylic acid group makes it a potential starting material for the synthesis of other compounds and pharmaceuticals. Overall, this compound has potential uses in the development of new drugs and pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 138775-03-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,7,7 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 138775-03:
(8*1)+(7*3)+(6*8)+(5*7)+(4*7)+(3*5)+(2*0)+(1*3)=158
158 % 10 = 8
So 138775-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H24N2O6/c1-18(2,3)26-17(24)20-10-9-19(11-14(20)15(21)22)16(23)25-12-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,21,22)/t14-/m0/s1

138775-03-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names (2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenylmethoxycarbonylpiperazine-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138775-03-8 SDS

138775-03-8Relevant articles and documents

ISOBARIC MASS LABELS

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Paragraph 0023; 0024; 0174; 0175, (2019/01/04)

The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: [in-line-formulae]X-L-M-Re[/in-line-formulae] wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a ma

Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent

Firth, James D.,O'Brien, Peter,Ferris, Leigh

, p. 651 - 659 (2016/01/29)

A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation-substitution of an α-methylbenzyl-functionalized N-Boc piperaz

Asymmetric synthesis of chiral organofluorine compounds: Use of nonracemic fluoroiodoacetic acid as a practical electrophile and its application to the synthesis of monofluoro hydroxyethylene dipeptide isosteres within a novel series of HIV protease inhibitors

Myers,Barbay,Zhong

, p. 7207 - 7219 (2007/10/03)

Two stereoselective routes to a series of diastereomeric inhibitors of HIV protease, monofluorinated analogues of the Merck HIV protease inhibitor indinavir, are described. The two routes feature stereoselective construction of the fluorinated core subunits by asymmetric alkylation reactions. The first-generation syntheses were based on the conjugate addition of the lithium enolate derived-from pseudoephedrine α-fluoroacetamide to nitroalkene 12, a modestly diastereoselective transformation. A more practical second-generation synthetic route was developed that is based on a novel method for the asymmetric synthesis of organofluorine compounds, by enolate alkylation using optically active fluoroiodoacetic acid as the electrophile in combination with a chiral amide enolate. Resolution of fluoroiodoacetic acid with ephedrine provides either enantiomeric form of the electrophile in ≥96% ee. Alkylation reactions with this stable and storable chiral fluorinated precursor are shown to proceed in a highly stereospecific manner. With the development of substrate-controlled syn- or anti-selective reductions of α-fluoro ketones 44 and 45 (diastereomeric ratios 12:1-84:1), efficient and stereoselective routes to each of the four targeted inhibitors were achieved. The optimized synthetic route to the most potent inhibitor (syn,syn-4, Ki = 2.0 nM) proceeded in seven steps (87% average yield per step) from aminoindanol hydrocinnamide 40 and (S)-fluoroiodoacetic acid, and allowed for the preparation of more than 1 g of this compound. The inhibition of HIV-1 protease by each of the fluorinated inhibitors was evaluated in vitro, and the variation of potency as a function of inhibitor stereochemistry is discussed.

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