13880-05-2

Basic information

• Product Name: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
• Synonyms: 2-ACRYLAMIDO-2-HYDROXYMETHYL-1,3-PROPANEDIOL;ACRYLAMIDOTRISHYDROXYMETHYLMETHANE;N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE;N-(2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL)-2-PROPENAMIDE;N-[TRIS(HYDROXYMETHYL)METHYL]ACRYLAMIDE;N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]acrylamide;NAT, TRIS-acrylamide;Acryloylaminomethylidynetrimethanol
• CAS NO: 13880-05-2
• Molecular Formula: C₇H₁₃NO₄
• Molecular Weight: 175.18
• EINECS: 237-645-4
• Product Categories: Naphthyridine,Quinoline
• Mol File: 13880-05-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 136-141 °C(lit.)
• Boiling Point: 510.8 °C at 760 mmHg
• Flash Point: 262.7 °C
• Appearance: White crystals or crystalline powder
• Density: 1.272 g/cm³
• Vapor Pressure: 1.43E-12mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 0-6°C
• PKA: 12.74±0.46(Predicted)
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive & Hygroscopic
• BRN: 2081162
• CAS DataBase Reference: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE(13880-05-2)
• EPA Substance Registry System: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE(13880-05-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• F: 8-10-21
• Hazardous Substances Data: 13880-05-2(Hazardous Substances Data)

Usage

Chemical Properties

White crystals or crystalline powder

Uses

N-[Tris(hydroxymethyl)methyl] acrylamide is used to prepare N-(5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)-acrylamide by reaction with benzaldehyde.

InChI:InChI=1/C7H13NO4/c1-2-6(12)8-7(3-9,4-10)5-11/h2,9-11H,1,3-5H2,(H,8,12)

Upstream product

• 79-10-7 acrylic acid 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 814-68-6 acryloyl chloride 

Downstream Products

• 151734-48-4 N-(5-Hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)-acrylamide 
• 151734-53-1 Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(5-acryloylamino-2-phenyl-[1,3]dioxan-5-ylmethoxy)-tetrahydro-pyran-4-yl ester 
• 175401-30-6 3-Diphenylphosphanyl-N-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-propionamide 

Relevant articles and documents

A Serum-Tolerant Hydroxyl-Modified Polyethylenimine as Versatile Carriers of pDNA/siRNA

The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacity than PEI25k. Specially, the transfection efficiency of PT26/DNA is 29-fold higher than that of PEI25k in HeLa cells in serum-containing medium. The PTn/siRNA complexes show superior knockdown effect in CT26 cells in serum-containing medium. In addition, flow cytometry analysis shows that the PTns can efficiently mediate the entry of nucleic acids into the cell. Thus, PTns are potentially applicable as non-viral carriers of nucleic acids and warrant further development for use in gene therapy. A series of serum-tolerant PTn conjugates, by introduction of hydroxyl groups onto PEI25k, is designed as dual carriers for nucleic acids delivery. The transfection efficiency of PTn can be up to 29.1-fold higher than that of PEI25k in the serum-containing medium. Meanwhile, PTn with higher endocytosis is more effective in luciferase knockdown compared to PEI25k in the serum-containing medium.

Microspheres useful for therapeutic vascular embolization

Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.

Ink composition for inkjet printing, ink set, and image forming method

The invention provides an ink composition for inkjet printing, the ink composition containing water, a coloring material, a polymerizable compound, a polymerization initiator represented by the following Formula (X), and polymer particles having a glass transition temperature of 90°C or higher, a mass ratio of the polymer particles to the polymerization initiator represented by Formula (X) being in a range of from 1:10 to 10:1 1 [in Formula (X), each of RX1, RX2, RX3, and RX4 independently represents a hydrogen atom or a substituent; and n represents an integer from 1 to 4].