13882-59-2

Basic information

• Product Name: benzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone
• Synonyms: benzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone
• CAS NO: 13882-59-2
• Molecular Formula: C₁₈H₂₃N₇O₂
• Molecular Weight: 369.42092
• Mol File: 13882-59-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: benzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone(13882-59-2)
• EPA Substance Registry System: benzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone(13882-59-2)

Safety Data

• Hazardous Substances Data: 13882-59-2(Hazardous Substances Data)

Upstream product

• 13017-47-5 4,4’-(6-hydrazineyl-1,3,5-triazine-2,4-diyl)dimorpholine 
• 100-52-7 benzaldehyde 
• 7597-22-0 2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine 

Relevant articles and documents

Synthesis and characterization of new series of 1,3-5-Triazine hydrazone derivatives with promising antiproliferative activity

A new series of s-triazine hydrazone derivatives was prepared based on the reaction of 6-hydrazino-2,4-disubstituted-s-triazine with p-substituted benzaldehyde derivatives using a straightforward synthetic pathway. The antiproliferative activity of all synthesized compounds was evaluated against two human cancer cell lines; breast cancer MCF-7 and colon carcinoma HCT-116 using MTT assay. Among all, 11 compounds have shown strong to moderate antiproliferative activity with IC50 values in the range 1.01–18.20 μM in MCF-7 and 0.97–19.51 μM in HCT-116. The best results were obtained with 4,4’-(6-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3,5-triazine-2,4-diyl) dimorpholine 11 (IC50 = 1.0 μM and 0.98 μM in MCF-7 and HCT-116 cell lines, respectively). The substituents on the s-triazine core as well as the substituent at the benzylidene moiety have a great effect on the antiproliferative activity. Whereas compounds containing dimorpholino-striazine derivatives 8a–e showed more potent antiproliferative in MCF-7 compared to their analogs 7a–f (compounds containing two-piperidine rings), compounds containing one piperidine and one morpholine ring 9a–f showed better IC50 values in the range 10.4–22.2 μM. On the other hand, compounds containing two-piperidine rings 7a–f showed more potent antiproliferative in HCT-116 (IC50 values in the range 8.8–19.5 μM) than their analogs 8a–e and 9a–f.