138854-19-0

Basic information

• Product Name: 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran
• Synonyms: 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran
• CAS NO: 138854-19-0
• Molecular Weight: 489.614
• Mol File: 138854-19-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran(138854-19-0)
• EPA Substance Registry System: 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran(138854-19-0)

Safety Data

• Hazardous Substances Data: 138854-19-0(Hazardous Substances Data)

Upstream product

• 767-00-0 4-cyanophenol 
• 138854-18-9 5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 139201-47-1 3-(5-Benzyloxy-2-phenethyl-2,3-dihydro-benzofuran-6-yl)-propan-1-ol 
• 138853-84-6 6-allyl-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 138854-09-8 5-(allyloxy)-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 138854-08-7 2,3-dihydro-5-methoxy-2-(2-phenylethyl)benzofuran 
• 139201-44-8 2-(1-hydroxy-2-phenylethyl)-5-methoxybenzofuran 
• 133174-25-1 2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 139201-45-9 5-methoxy-2-(2-phenylethyl)benzofuran 
• 122-78-1 phenylacetaldehyde 
• 13391-28-1 5-methoxybenzofuran 

Downstream Products

• 138854-20-3 5-(benzyloxy)-2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>benzofuran 
• 138853-91-5 2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>-5-benzofuranol 

Relevant articles and documents

Development of 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a Potent and Orally Active Inhibitor of 5-Lipoxygenase

Leukotrienes are potent biological mediators of allergic and antiinflammatory diseases and are derived from arachidonic acid through the action of the 5-lipoxygenase.In this study, the syntheses and comparative biological activities of three series of 2,3-dihydro-2,6-disubstituted-5-benzofuranols with various substituents on position 3 are described.Compounds from each series were evaluated for their ability to inhibit the production of leukotriene B4 (LTB4) in human peripheral blood polymorphonuclear (PMN) leukocytes and the 5-lipoxygenase reaction in cell-free preparations from rat PMN leukocytes.The structure-activity relationships of each series in vitro and in vivo are presented.The bioavailability, metabolism, and toxicity profile of each series are discussed.The series with no substituent at position 3 was the most potent and among the compounds in that series 2,3-dihydro-6-(3-phenoxypropyl)2-(2-phenylethyl)-5-benzofuranol (46, L-670,630) was chosen for further development.