1388816-87-2

Upstream product

• 313339-35-4 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 313339-36-5 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxamide 
• 1386949-15-0 tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 

Downstream Products

• 1388816-88-3 tert-butyl 4-(4-(8-carbamoyl-5-(methylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-89-4 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X1, X2, X3, X4, R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.