313339-36-5

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new medicines with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxamide is utilized as a precursor in the production of crop protection products. Its incorporation into these products can contribute to the enhancement of agricultural yields by protecting crops from pests and diseases.

InChI:InChI=1/C6H5Cl2N3OS/c1-13-6-10-3(7)2(5(9)12)4(8)11-6/h1H3,(H2,9,12)

Upstream product

• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 313339-35-4 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 

Downstream Products

• 1388816-91-8 tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1386949-15-0 tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-87-2 tert-butyl 4-(4-(5-carbamoyl-6-hydrazinyl-2-(methylthio)pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-88-3 tert-butyl 4-(4-(8-carbamoyl-5-(methylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-89-4 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-97-4 tert-butyl 4-(4-(8-carbamoyl-5-(methylthio)tetrazolo[1,5-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-99-6 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)tetrazolo[1,5-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388817-20-6 tert-butyl 4-(4-(6-amino-5-carbamoyl-2-(methylthio)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1388817-21-7 tert-butyl 4-(4-(6-amino-5-carbamoyl-2-(2,6-dichlorobenzyl)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1388817-22-8 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)imidazo[1,2-c]pyrimidin-7-ylamino)phenyl)piperazine-1-carboxylate 
• 1386952-42-6 5-(2,6-dichlorobenzyl)-7-{[4-(piperazin-1-yl)phenyl]amino}imidazo[1,2-c]pyrimidine-8-carboxamide 
• 1254057-15-2 4-chloro-2-(methylsulfanyl)-6-{[3-(methylsulfonyl)phenyl]amino}pyrimidine-5-carboxamide 
• 1254057-16-3 2-(methylsulfanyl)-4-{[3-(methylsulfonyl)phenyl]amino}-6-oxo-1,6-dihydropyrimidine-5-carboxamide 

Relevant academic research and scientific papers

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X1, X2, X3, X4, R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.