138884-10-3Relevant academic research and scientific papers
Synthesis of Gadolinium (+/-)-10-(1-Hydroxypropan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltriacetate via Tribenzyl 1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylate
Prasad, J. Siva,Okuniewicz, Frank J.,Delaney, Edward J.
, p. 3329 - 3332 (2007/10/02)
The synthesis of monogadolinium 10-(1-hydroxypropan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltriacete 12 has been achieved trough a multistep sequence.The key step in the synthesis was the reaction of the previously unknown tribenzyl 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 6 with ethyl 2-(trifluoromethylsulphonyloxy)propionate 4 to give 7.Reduction of 7 with LiBH4/9-OMe-BBN, followed by hydrogenolysis of the protecting groups (Z groups) yielded 2-(1,4,7,10-tetraazacyclododec-1-yl)propanol 10.The monosubstituted macrocycle 10 was alkylated withbromoacetic acid and then complexed with gadolinium oxide to yield the title compound.
