1388851-19-1Relevant articles and documents
Reaction of 5-azacytosine with 3-methyl-1-phenyl-5-pyrazolone
Azev,Teplyashina,Golomolzin
, p. 1114 - 1115 (1997)
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New Synthetic Potential of Pteridine Derivatives: Direct Substitution of H in 1,3-Dimethyllumazine During Reaction with C-Nucleophiles
Azev, Yu. A.,Ermakova,Gibor,Ezhikova,Kodess,Chupakhin
, p. 373 - 375 (2016)
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Interaction of fervenulin-4-oxide with 1-phenyl-3-methylpyrazol-5-one in the absence of bases
Azev,Teplyashina
, p. 97 - 98 (1998)
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Investigation of tetrazine reactivity towards C-nucleophiles: Pyrazolone-based modification of biomolecules
Renault, Kévin,Guillou, Clément,Renard, Pierre-Yves,Sabot, Cyrille
, p. 388 - 396 (2019)
Chemoselective, biocompatible ligation reactions are the key components for efficient and modular access to biomolecular scaffolds. Tetrazine ligation leads to the formation of a mixture of isomers, which makes reaction monitoring, purification and characterization of conjugates difficult. We report herein a modified tetrazine ligation strategy based on the use of a pyrazolone coupling partner, which provides a single molecule conjugate.
Reaction of 2-chloro-1-alkyl-1H-indole-3-carbaldehydes with barbituric acids and 5-methyl-2-phenyl-2,4-dihydropyrazol-3-one. Formation of compound with extremely short intramolecular hydrogen bond in eight-membered pseudocycle
Suzdalev, Konstantin F.,Babakova, Maria N.,Kartsev, Victor G.,Krasnov, Konstantin A.
, p. 64 - 75 (2015/05/12)
New indolin-2-one derivatives, containing in its molecules eight-membered pseudo-cycle with unusually short intramolecular hydrogen bond in OHO-bridge have been synthesized by reaction of 2-chloro-1-alkyl-1H-indole-3-carbaldehyde with barbituric acids or 5-methyl-2-phenyl-2,4-dihydropyrazol-3-one. Under the action of amines they undergo fragmentation to 5-aminomethylenebarbituric acids or 4-aminomethylenepyrazolones and 1-alkyl-1,3-dihydroindol-2-ones.