138907-81-0

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: ASINEX-REAG BAS 10145338;1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
• CAS NO: 138907-81-0
• Molecular Formula: C₁₀H₇FN₂O₂
• Molecular Weight: 206.17
• Mol File: 138907-81-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(138907-81-0)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(138907-81-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 138907-81-0(Hazardous Substances Data)

Usage

Chemical structure

A pyrazole derivative with a carboxylic acid functional group attached to the pyrazole ring and a 4-fluoro-phenyl group attached to the first position of the pyrazole ring.

Industry use

Pharmaceutical industry

Purpose

Building block for the synthesis of various drugs and bioactive molecules

Therapeutic applications

Anti-inflammatory and anticancer properties

Drug candidate potential

Ability to modulate various biological processes

Additional investigation

Potential as a fluorescent labeling agent for biological imaging and research purposes

Upstream product

• 138907-73-0 ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate 
• 138907-68-3 ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate 
• 371-14-2 4-fluorophenylhydrazine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 288250-13-5 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)pyrrolecarboxamide 
• 288249-90-1 N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine 
• 1576240-34-0 (S)-tert-butyl 2-(4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate 
• 1415757-43-5 tert-butyl (RS)-2-(3-chloro-4-(1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)phenyl)morpholine-4-carboxylate 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.