1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
CAS No.:138907-81-0
Molecular Formula:C10H7FN2O2
Molecular Weight:206.176
Hs Code.:2933199090
DSSTox Substance ID:DTXSID90390200
Wikidata:Q82186689
ChEMBL ID:CHEMBL4859719
Mol file:138907-81-0.mol

Synonyms:138907-81-0;1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid;1-(4-Fluoro-phenyl)-1H-pyrazole-4-carboxylic acid;1-(4-fluorophenyl)pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-(4-fluorophenyl)-;SCHEMBL2850367;CHEMBL4859719;OSM-S-245;DTXSID90390200;MFCD07186399;STK691800;AKOS000191159;KS-6879;AM20020463;BB 0219786;CS-0183139;EN300-198739;P19029;1-(4-fluorophenyl)-1H-pyrazole-4-carboxylicacid;Z317041810;1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylic acid, AldrichCPR

Suppliers and Price of 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicAcid
25mg
$ 45.00

SynQuest Laboratories
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylic acid 95%
1 g
$ 688.00

Matrix Scientific
1-(4-Fluoro-phenyl)-1H-pyrazole-4-carboxylic acid
1g
$ 378.00

Heterocyclics
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicacid 95%
1g
$ 250.00

Heterocyclics
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicacid 95%
5g
$ 800.00

Crysdot
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicacid 97%
5g
$ 874.00

Apolloscientific
1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicacid 95%
1g
$ 430.00

American Custom Chemicals Corporation
1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 95.00%
500MG
$ 802.73

AK Scientific
1-(4-Fluoro-phenyl)-1H-pyrazole-4-carboxylicacid
500mg
$ 589.00

AK Scientific
1-(4-Fluoro-phenyl)-1H-pyrazole-4-carboxylicacid
250mg
$ 570.00

Total 8 raw suppliers

Chemical Property of 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

PSA：55.12000
LogP:1.70960
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:206.04915563
Heavy Atom Count:15
Complexity:242

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Fluorophenyl)-1H-pyrazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1N2C=C(C=N2)C(=O)O)F

Technology Process of 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

There total 4 articles about 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 138907-73-0
ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 138907-81-0
1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate; With sodium hydroxide; In ethanol; for 22h; Reflux;

With hydrogenchloride; In water; at 20 ℃;
DOI:10.2174/1570178617999200728215322

Reference yield:

: 138907-68-3
ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 138907-81-0
1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: isopentyl nitrite / tetrahydrofuran / 2 h / Heating / reflux

2: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux

With sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; ethanol; water;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 138907-81-0
1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 1 h / Heating / reflux

2: isopentyl nitrite / tetrahydrofuran / 2 h / Heating / reflux

3: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux

With sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; ethanol; water;