1389339-40-5Relevant academic research and scientific papers
Synthesis and biological evaluation of some new thiazolo[2,3-b]quinazolines and their derivatives
Gupta, Richa,Chaudhary
, p. 2113 - 2116 (2012/08/07)
9-Methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinzoline-2(1H)-thione (2), obtained by the condensation of (E)-2-benzylidene-7-methoxy-3,4- dihydronaphthalen-1(2H)-one (1) with thiourea, on reaction with chloroacetic acid, α-bromopropionic acid and 1,2-dibromoethane furnishes compounds, 3, 4 and 5 and not their other possible isomers, 7, 8 and 9, respectively. Arylidene thiazolidinones 6 have been obtained by two routes. Compounds 3-5 represent a novel heterocyclic system. The structural assignments of 3, 4 and 5 are based on elemental analysis, 1H NMR, IR and mass spectral data. The condensed 4-thiazolidinones (3-5) and their 2-arylidene derivatives (6a-c) were screened for antimicrobial activity and showed promising inhibition of S. aureus, C. diphtheriae, P. aeruginosa and E. coli bacteria.
