418798-38-6

Upstream product

• 6836-19-7 7-Methoxy-1-tetralone 
• 100-52-7 benzaldehyde 
• 17356-08-0 thiourea 
• 41526-55-0 2-phenylmethylene-7-methoxy-1-tetralone 
• 1389339-37-0 (2E)-2-benzylidene-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 

Downstream Products

• 1389339-41-6 (E)-2-methoxy-10-(4-chlorobenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 1389339-40-5 2-methoxy-7-phenyl-6,7,9,10-tetrahydro-5H-benzo[h]thiazolo[2, 3-b]quinazoline 
• 1389339-38-1 2-methoxy-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo-[2,3-b]quinazolin-9(6H)-one 
• 1389339-39-2 2-methoxy-10-methyl-7-phenyl-7,10-dihydro-5Hbenzo[h]thiazolo-[2,3-b]quinazolin-9(6H)-one 

Relevant academic research and scientific papers

Efficient ionic liquid-catalysed synthesis and antimicrobial studies of 4,6-diaryl- and 4,5-fused pyrimidine-2-thiones

One-pot three-component condensation of aromatic ketones (1-tetralones, acetophenones, indane-1,3-dione), substituted aromatic aldehydes and thiourea in the presence of N-methylpyridinium tosylate under solvent free conditions at 100-110 °C for 2-4 h afforded tetrahydrobenzo[h]quinazoline-2-thiones, pyridimidine-2-thiones and indeno-pyrimidine-2-thiones in excellent yields. All synthesised thiones were screened for their antimicrobial activities.

Synthesis and biological evaluation of some new thiazolo[2,3-b]quinazolines and their derivatives

9-Methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinzoline-2(1H)-thione (2), obtained by the condensation of (E)-2-benzylidene-7-methoxy-3,4- dihydronaphthalen-1(2H)-one (1) with thiourea, on reaction with chloroacetic acid, α-bromopropionic acid and 1,2-dibromoethane furnishes compounds, 3, 4 and 5 and not their other possible isomers, 7, 8 and 9, respectively. Arylidene thiazolidinones 6 have been obtained by two routes. Compounds 3-5 represent a novel heterocyclic system. The structural assignments of 3, 4 and 5 are based on elemental analysis, 1H NMR, IR and mass spectral data. The condensed 4-thiazolidinones (3-5) and their 2-arylidene derivatives (6a-c) were screened for antimicrobial activity and showed promising inhibition of S. aureus, C. diphtheriae, P. aeruginosa and E. coli bacteria.