138950-23-9

Usage

Physical State

Colorless liquid

Odor

Strong, pungent

Usage

Solvent in various industrial applications, production of pharmaceuticals, perfumes, and other organic compounds, intermediate in the synthesis of agrochemicals and specialty chemicals

Hazardous

Yes, due to potential health effects

Safety Precautions

Proper handling required

Upstream product

• 104764-35-4 (E/Z)-1-phenyl-3,3,3-trifluoro-1-trimethylsiloxypropene 
• 100-52-7 benzaldehyde 
• 103654-96-2 1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol 

Downstream Products

• 709-21-7 3,3,3-trifluoro-1-phenylpropan-1-one 
• 2340-22-9 methyl phenyl(3,3,3-trifluoro-1-phenylpropoxy)carbamate 

Relevant academic research and scientific papers

Reductive modification of difluoromethylene moiety in pentafluoropropionyl group

The reductive Mg-promoted defluorinative-silylation of 2,2,3,3,3-pentafluoropropiophenone readily produces the α-trifluoromethyl enol silyl ether, which then react with electrophiles to give a variety of 2-substituted-3,3,3-trifluoropropiophenones in excellent yields. The same protocol is applicable for the preparation of enol silyl ether of 3,3,3-trifluoropropiophenone. Fluoride ion catalyzed 1,2-desilylative-defluorination of 2,3,3,3-tetrafluoro-2-trimethylsilyloxypropiophenone provided 3,3,3-trifluoro-1-phenyl-1,2-propanedione in a good yield.

Electroreductive coupling of halofluoro compounds with aldehydes

Electroreductive intermolecular coupling of halofluoro compounds such as 1,1,1-trichloro-2,2,2-trifluoroethane, methyl chlorodifluoroacetate, and perfluoroalkyl halides with aldehydes took place effectively in the presence of chlorotrimethylsilane and one of the coupling products, 2,2-dichloro-3,3,3-trifluoro-1-phenyl-1-propranol, was selectively convertible to a variety of compounds with using the electroreduction as a key reaction.